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Exploring the Role of ADAM17 in Vascular Smooth Muscle Cells and Macrophages Within the Atherosclerotic Plaque
DownloadSpring 2024
Atherosclerosis, characterized by arterial fat deposits, is the root cause of many cardiovascular diseases. Plaque deposition results from a series of events initiated by elevated plasma cholesterol, inflammation of the arterial wall, cholesterol uptake, macrophage-derived foam cell formation,...
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Formation of taste-active metabolites in sourdough fermentation and the fermentation of plant-based cheese analogues
DownloadSpring 2024
Fermentation is an oldest and effective method to generate taste-active compounds which contribute to food taste. The aim of this PhD dissertation was to investigate the synthetic mechanism of taste-active γ-glutamyl dipeptides during sourdough fermentation and the fermentation of plant-based...
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Spring 2024
Searching for programmatic policies to solve a reinforcement learning problem can be challenging, particularly when dealing with domain-specific languages (DSLs) that define policies with internal states for partially observable Markov decision processes (POMDPs). This is because they lead to...
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Spring 2024
Recent advances in reinforcement learning (RL) and Human-in-the-Loop (HitL) learning have made human-AI collaboration easier for humans to team with AI agents. Leveraging human expertise and experience with AI agents in intelligent systems can be efficient and beneficial. Still, it is unclear to...
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Spring 2024
Most quantum computers are based on elements with many addressable states, yet restrict themselves to a two-level subset, a qubit. In principle, more states could be used in each element to form a d-dimensional qudit, increasing the Hilbert space dimension and thus the computational power of the...
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Influence of Precipitation, Temperature, and Climate Change on Landslide Hazards in Western Canada
DownloadSpring 2024
Canada experiences a significant number of landslides each year, posing substantial risks to safety, infrastructure, economic activities, and the environment. Over the last two and a half centuries, Canada has witnessed approximately 800 fatalities attributed to landslides, which has made...
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Microbial Electrolysis Cell-Assisted Anaerobic Digestion for Enhancing Biomethane Recovery from High-strength Wastewater
DownloadSpring 2024
Anaerobic digestion (AD) is a sustainable method for treating high-strength wastewater while concurrently recovering biomethane. Nevertheless, factors such as low temperature and complex organic substrates can limit digestion kinetics, with hydrolysis and methanogenesis as the primary...
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Spring 2024
A diffuse interface model to simulate a system of two immiscible liquids with surfactants is proposed. This model is based on a modified Ginzburg-Landau free energy functional to account for non-ionic soluble surfactants and couples the Navier-Stokes equations with two Cahn-Hilliard equations...
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In-silico Methods for Drug Discovery: Applications of Molecular Dynamics, Drug Docking, and Machine Learning
DownloadSpring 2024
Drug discovery is a venture that is costly in both time and money. In-silico methods are a core part of biomedical research, from traditional tools such as drug docking and molecular dynamics to newer machine learning frameworks, all of which are more efficient in both time and cost compared to...
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Spring 2024
Hydrogen as a fuel has the potential to reduce tailpipe carbon dioxide emissions of vehicles to near-zero, while also allowing for the generation of a hydrogen-based economy and lowering humanity's dependence upon oil. Hydrogen-diesel dual fuel combustion, where hydrogen and diesel are combusted...