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A General Route to meta-(Arylsulfanyl) and meta-(Alkylsulfanyl) Substituted Phenols and Synthetic Studies on Sorbicillactones A and B
DownloadSpring 2022
Chapter 1 describes a general route for making meta-(arylsulfanyl) and meta-(alkylsulfanyl) phenols using DBU assisted aromatization developed in this laboratory. Thismethod is general and enables the construction of the C-S bond without using high temperatures or transition metal catalyst. The...
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Improving Child and Adolescent Mental Health Services: A Qualitative and Quantitative Exploration into the Current State of Services in Alberta, Canada
DownloadSpring 2023
Background There is a paucity of evidence-based research aimed at determining best-practice treatment in the context of child and adolescent mental health services (CAMHS). Despite the high prevalence of mental illness in youth, no gold-standard for treatment currently exists. Assessment tools...
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Spring 2023
The rotating B0 linac-MR is a new type of radiotherapy treatment machine that combines radiation delivery from a linear accelerator (linac) with a magnetic resonance imaging (MRI) system for real-time tumour tracking. This kind of combined technology aims to achieve tighter margins in cancer...
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Spring 2023
There has been a renewed interest in commonsense as a stepping stone toward achieving human-level intelligence. By digesting enormous amounts of data in different forms, such as visual, lingual, and sensory, humans are able to create a world model for themselves. It is hypothesized that this...
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Identification and characterization of sperm-specific components required for female meiosis in C. elegans
DownloadSpring 2022
In most sexually reproducing animals, sperm entry provides the signal to initiate the final stages of female meiosis. The molecular mechanism of this process is still unclear. In C. elegans, three maternally-expressed paralogs, memi-1, 2 and 3 (meiosis-to-mitosis) are required for sensing sperm...
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Novel Isotope Labeling Strategies for NMR-Based Structure Determination of High Molecular Weight Proteins
DownloadSpring 2023
Solution NMR studies of high molecular weight proteins suffer from inadequate side-chain information and rapid signal decay. Selective 1H, 13CH3-methyl labelling of perdeuterated proteins has been the standard approach addressing these limitations but suffers from a lack of information about the...
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Spring 2023
AlbertaSat is a group of researchers and students at the University of Alberta who are developing low-cost satellites with open-source software that follow the CubeSat form factor. It is one of the projects funded by the Canadian CubeSat Project, whose goal is to provide a hands-on satellite...
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Spring 2023
Five-year overall survival for gastric cancer in Canada is only 25%. Standard of care treatment using neoadjuvant chemotherapy and surgery achieves partial or complete treatment response in only 40% of patients. Additional strategies and methods to discover novel therapies and optimize existing...