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Skip to Search Results- 1Abuetabh, Yasser H
- 1Albahrani, Redha Mohammed
- 1Allen,Richelle J
- 1Almizraq, Ruqayyah J
- 1Bahitham, Wesam Ahmad
- 1Beesoon,Sanjay
- 5Li, Xing-Fang (Laboratory Medicine and Pathology)
- 2Acker, Jason (Laboratory Medicine and Pathology)
- 2Lai, Raymond (Laboratory Medicine and Pathology)
- 2Le, X. Chris (Laboratory Medicine and Pathology)
- 2Sergi, Consolato (Department of Laboratory Medicine and Pathology and Department of Pediatrics)
- 1Acker, Jason (Supervisor, Department of Laboratory Medicine and Pathology)
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Detection of Shiga Toxin-Producing Escherichia coli Using Loop Mediated Isothermal Amplification
DownloadFall 2013
Shiga toxin-producing Escherichia coli (STEC) is a worldwide health concern. To detect STEC, a loop mediated isothermal amplification reaction (LAMP) was optimized to detect shiga toxin genes. LAMP’s performance was compared to conventional and real-time (RT) PCR using two product detection...
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Spring 2013
Binding-induced DNA assembly (BINDA) was initially developed for protein detection. To demonstrate the homogeneous detection of carbohydrates using this principle, a BINDA assay for the pancreatic cancer marker carbohydrate antigen 19-9 (CA 19-9) was developed. The assay uses two DNA- antibody...
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Differential Expression of TWSG1, BMP4 and Shh Morphogens Signaling Proteins in Hepatocellular Carcinoma and Cholangiocellular Carcinoma
DownloadSpring 2014
Hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CCA) constitute two of the most common liver malignancies in adults. The molecular mechanisms underlying their development remain poorly understood. Morphogen proteins, including the hedgehog and the bone morphogenetic proteins...
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Drug Resistance in Breast Cancer: Characterization of Rationally Designed Paclitaxel Analogs in Model Systems
DownloadFall 2013
Breast cancer is a leading cause of cancer related deaths among women in the developed world. Treatment options for breast cancer include taxanes, which mediate cytotoxic effects by inducing microtubule polymerization which impedes cell division. Taxane resistant breast cancer is a mounting...
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Fall 2013
Breast cancer is the most common cancer among women in the developed world. The disease results from the combined effects of genetic, environmental, reproductive and lifestyle risk factors. Germline DNA variations identified thus far by linkage and genome-wide association studies (GWASs) account...
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Spring 2014
Perfluoroalkyl acids (PFAAs) are a family of emerging toxicants that are non-biodegradable, and have the potential to bioconcentrate and biomagnify. In an attempt to answer questions about human exposure to PFAAs, and subsequent human disposition of these compounds which have public health...
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Identifying and Characterizing Red Blood Cell Microvesiculation, Phosphatidylserine and CD47 Expression As a Predictor of Red Blood Cell In Vitro Quality Following Hypothermic Storage
DownloadSpring 2013
Abstract: Proper preservation of the quality of stored red blood cells (RBC) is fundamental for successful blood transfusion. RBC microparticles (RMPs) have been shown to be harmful effectors of inflammation and coagulation posttransfusion, as well as in vitro indicators of RBC function and...
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Spring 2013
Cholangiocarcinoma (CCA) represents a very devastating liver neoplasm, whose incidence is increasing worldwide. CCA is often diagnosed in its late stages, and the treatment options for this disease are restricted to surgical resection and liver transplantation. Our group demonstrated that...
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Spring 2013
The success of cellular cryopreservation is indicated by the state of post-thawed cells. Using human umbilical vein endothelial cells as a model, the cryobiological response to interrupted cooling protocols was evaluated with a combination of fluorescence microscopy and flow cytometry....
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Mutant Group B Streptococcus surface expressed Phosphoglycerate kinase (PGK) with reduced plasminogen binding
DownloadSpring 2014
Group B streptococcus (GBS) is a Gram-positive streptococcus bacterium that can cause severe invasive disease in the human neonate. This can manifest as pneumonia, septicemia and meningitis. While antibiotic prophylaxis has reduced the incidence GBS disease in the neonatal population, it is still...