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Differential Expression of TWSG1, BMP4 and Shh Morphogens Signaling Proteins in Hepatocellular Carcinoma and Cholangiocellular Carcinoma

  • Author / Creator
    Albahrani, Redha Mohammed
  • Hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CCA) constitute two of the most common liver malignancies in adults. The molecular mechanisms underlying their development remain poorly understood. Morphogen proteins, including the hedgehog and the bone morphogenetic proteins pathway fulfill a major role in embryonic development. Consequently, alterations in these proteins may cause embryonic defects. Furthermore, abnormal expression of morphogen proteins is found to correlate with cancer development and progression. This thesis has demonstrated the differential expression and co-localization of the morphogen proteins, including sonic hedgehog (Shh), bone morphogenetic protein (BMP)-4 and twisted gastrulation protein (TWSG)-1 in human HCC and CCA tumors and cell lines. These proteins are strongly expressed in CCA more than in HCC. Overall, these findings suggest that morphogen proteins may play a crucial role during liver carcinogenesis and progression, specifically in CCA. Moreover, these proteins can serve as diagnostic biomarkers for HCC and CCA.

  • Subjects / Keywords
  • Graduation date
    2014-06
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/R3W669G1R
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Master's
  • Department
    • Medical Sciences- Laboratory Medicine and Pathology
  • Supervisor / co-supervisor and their department(s)
    • Sergi, Consolato (Department of Laboratory Medicine and Pathology and Department of Pediatrics)
    • Keelan, Monika (Department of Laboratory Medicine and Pathology)
  • Examining committee members and their departments
    • Persad, Sujata (Department of Pediatrics)
    • Martin, Jonathan (Department of Laboratory Medicine and Pathology)
    • Bamforth, Fiona (Department of Laboratory Medicine and Pathology)