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Skip to Search Results- 3Deyholos, Michael K.
- 2Harrington, Michael J.
- 2Hegele, Robert A.
- 2Wang, J.
- 2Young, T. Kue
- 1 Hu, Songnian
- 39Graduate and Postdoctoral Studies (GPS), Faculty of
- 39Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 8Biological Sciences, Department of
- 5Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 3Biological Sciences, Department of/Other Publications (Biological Sciences)
- 2Roy Berg Kinsella Research Ranch
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Genome-wide analysis of zygotic linkage disequilibrium and its components in crossbred cattle
Download2012
Jiang, Q., Wang, Z., Yang, R. C., Moore, S. S.
Background Linkage disequilibrium (LD) between genes at linked or independent loci can occur at gametic and zygotic levels known asgametic LD and zygotic LD, respectively. Gametic LD is well known for its roles in fine-scale mapping of quantitative trait loci, genomic selection and evolutionary...
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Anesthesia and the Aging Vasculature: Effects of Propofol on Hemodynamics and Vascular Function
DownloadSpring 2014
An increasing life expectancy in Canada has resulted in increasing proportions of elderly patients requiring anesthetic care for surgical procedures. Aging is associated with cardiovascular changes resulting in increased vasoconstriction and hypertension, and medications such as angiotensin...
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Fall 2010
Improving feed efficiency has become a top priority in beef cattle production because of the rapidly increasing cost of feed provision. However, because of the expense associated with collecting individual animal feed intake data, only a relatively small number of animals have been tested,...
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Regulation of Cardiac Gap Junctional Communication: Metabolic regulation of Cx40 and Cx43 via phosphorylation
DownloadFall 2015
Alterations in myocardial metabolism and cardiac electrophysiology associated with structural heart disease generate lethal arrhythmias. Differential levels of energy (ATP) supply and demand are generated with structural heart disease that is expected to activate 5’-amp activated protein kinase...
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Fall 2015
Polycystic kidney disease (PKD) protein 2 Like 1 (PKD2L1), also called transient receptor potential polycystin-3 (TRPP3), regulates Ca2+-dependent hedgehog signalling in primary cilia, intestinal development and sour tasting but with an unclear mechanism. PKD2L1 is a Ca2+-permeable cation channel...
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Spring 2012
Neuropathic pain afflicts 1.5-3% of the general population. It can be initiated by traumatic nerve injuries or diseases such as diabetic or post-herpetic neuropathy. Neuropathic pain is often initiated by abnormal spontaneous activity in sensory neurons and this provokes increased excitability of...
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Pharmacological and Fluorometric Assessment of Neuronal KCNQ Channels, and Implications for Understanding Neurological Disease
DownloadSpring 2020
Epilepsy affects 60 million people worldwide, and encompasses the most common forms of neurological disorders. Epilepsy manifests in diverse ways in patients, ranging from mild cognitive effects, to seizures, to the more severe epileptic encephalopathy. While many pharmacological approaches exist...
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Fall 2019
The development of efficacious anticancer therapies has significantly improved the prognosis of childhood cancer patients at the price of predisposing survivors to extensive chronic health problems. Although not fatal, reducing treatment-related hearing loss (ototoxicity) among childhood cancer...
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Common variants APOC3, APOA5, APOE and PON1 are associated with variation in plasma lipoprotein traits in Greenlanders
Download2007-12-01
Lahiry, Piya, Ban, Matthew R., Pollex, Rebecca L., Sawyez, Cynthia G., Huff, Murray W., Young, T. Kue, Bjerregaard, Peter, Hegele, Robert A.
"Objectives: We undertook studies of the association between common genomic variations in APOC3, APOA5, APOE and PON1 genes and variation in biochemical phenotypes in a sample of Greenlanders. Study Design: Genetic association study of quantitative lipoprotein traits. Methods: In a sample of...
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2000-08-01
Wang, Jian, Burnett, John R., Near, Susan, Young, T. Kue, Zinman, Bernard, Hanley, Anthony J. G., Connelly, Philip W., Harris, Stewart B., Hegele, Robert A.
"Mutations in ABCA1, a member of the ATP-binding cassette family, have been shown to underlie Tangier disease (TD) and familial hypoalphalipoproteinemia (FHA), which are genetic disorders that are characterized by depressed concentrations of plasma high density lipoprotein (HDL) cholesterol. An...