Common and Rare ABCA1 Variants Affecting Plasma HDL Cholesterol

• Author(s) / Creator(s)

  • Wang, Jian
  • Burnett, John R.
  • Near, Susan
  • Young, T. Kue
  • Zinman, Bernard
  • Hanley, Anthony J. G.
  • Connelly, Philip W.
  • Harris, Stewart B.
  • Hegele, Robert A.

• "Mutations in ABCA1, a member of the ATP-binding cassette family, have been shown to underlie Tangier disease (TD) and familial hypoalphalipoproteinemia (FHA), which are genetic disorders that are characterized by depressed concentrations of plasma high density lipoprotein (HDL) cholesterol. An important question is whether common variants within the coding sequence of ABCA1 can affect plasma HDL cholesterol in the general population. To address this issue, we developed a screening strategy to find common ABCA1 variants." (as cited in abstract)

• Date created

  2000-08-01

• Subjects / Keywords

  • DNA
  • Genetics
  • Complex disease
  • Susceptibility
  • Aboriginal

• Type of Item

  Article (Published)

• DOI

  https://doi.org/10.7939/r3-76y1-j635

• License

  Attribution 4.0 International