Common and Rare ABCA1 Variants Affecting Plasma HDL Cholesterol

Wang, Jian; Burnett, John R.; Near, Susan; Young, T. Kue; Zinman, Bernard; Hanley, Anthony J. G.; Connelly, Philip W.; Harris, Stewart B.; Hegele, Robert A.

doi:doi:10.7939/r3-76y1-j635

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Common and Rare ABCA1 Variants Affecting Plasma HDL Cholesterol

Author(s) / Creator(s)
"Mutations in ABCA1, a member of the ATP-binding cassette family, have been shown to underlie Tangier disease (TD) and familial hypoalphalipoproteinemia (FHA), which are genetic disorders that are characterized by depressed concentrations of plasma high density lipoprotein (HDL) cholesterol. An important question is whether common variants within the coding sequence of ABCA1 can affect plasma HDL cholesterol in the general population. To address this issue, we developed a screening strategy to find common ABCA1 variants." (as cited in abstract)
Date created

2000-08-01
Subjects / Keywords
Type of Item

Article (Published)
DOI

https://doi.org/10.7939/r3-76y1-j635
License

Attribution 4.0 International

Language
- English
Citation for previous publication
- Wang, J., Burnett, J. R., Near, S., Young, T. K., Zinman, B., Hanley, J. G., Connelly, P. W., Harris, S. B., & Hegele, R. A. (2000). Common and rare ABCA1 variants affecting plasma HDL cholesterol. Arteriosclerosis, Thrombosis and Vascular Biology, 20(8), 1983-1989. https://doi.org/10.1161/01.atv.20.8.1983
Source

<https://www.ahajournals.org/doi/10.1161/01.ATV.20.8.1983>
Link to related item

<https://v2.sherpa.ac.uk/id/publication/4070>