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Skip to Search Results- 8Department of Mathematical and Statistical Sciences
- 2Department of Biological Sciences
- 2Department of Medical Microbiology and Immunology
- 1Department of Agricultural, Food and Nutritional Science
- 1Department of Biochemistry
- 1Department of Civil and Environmental Engineering
- 2Li, Michael (Department of Mathematical and Statistical Sciences)
- 2Wang, Hao (Mathematical and Statistical Sciences)
- 1Dr. Michael Li (Department of Mathematical and Statistical Sciences)
- 1Dr. Richard Long (School of Public Health and Department of Medicine)
- 1Feldman, Mario (Biological Sciences)
- 1Foley, Edan (Medical Microbiology and Immunology)
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The Effectiveness of Tuberculosis Control Strategies that Target Social Determinants of Health in Three First Nations and Métis Communities: A Mathematical Modeling Approach
DownloadFall 2017
BACKGROUND: Despite the overall decline in tuberculosis (TB) incidence in Canada, rates among Indigenous peoples have not decreased since the late 1990s. On-going transmission associated with the time from the onset of symptoms to treatment have been identified as major contributor to the...
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The contribution of two phosphorylated surface modifications on the pathogenesis of Campylobacter upsaliensis
DownloadFall 2012
Campylobacter upsaliensis is a human pathogen most commonly associated with self-limiting gastroenteritis. Despite extensive epidemiological data indicating C. upsaliensis as an emerging pathogen, few studies have examined possible mechanisms of its virulence. The surface of C. upsaliensis is...
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Proliferative Signals Regulate Hemocyte Development and Intestinal Immunity in Drosophila melanogaster.
DownloadSpring 2015
The innate immune system is an ancient line of resistance against intrusive microbial threats. This system integrates cellular, humoral, and barrier defenses to generate a protective immune response. These divisions are indispensable and conserved between Drosophila and mammals. Hemocytes are the...
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Periodic solutions and bistability in a model for cytotoxic T-lymphocyte (CTL) response to human T-cell lymphotropic virus type I (HTLV-I)
DownloadFall 2009
HTLV-I is the first discovered human retrovirus and a causative agent of both adult T-cell leukemia (ATL) and HTLV-I-associated myelopathy (or tropical spastic paraparesis) (HAM/TSP). Previous models have been successful in providing insight into the progression of HTLV-I infection. The...
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Parameter Estimation of Mathematical Models: Estimation of the Burden of HIV Epidemics as a Case Study
DownloadFall 2016
Mathematical models are widely used to describe dynamics in various fields. In practice, it is necessary and important to determine model parameters based on existing data. A major challenge for parameter estimation under modeling framework lies in non-identifiability issue: parameter values on a...
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Molecular Regulation and Function of the Protein Tyrosine Kinase Pyk2 in Cytotoxic T Lymphocytes
DownloadFall 2013
Cytotoxic T lymphocytes (CTL) play a critical role in immune surveillance and elimination of virus-infected and malignant cells. CTL utilize two major cell-contact dependent mechanisms to kill antigen-bearing target cells. One mechanism involves the directional release of cytolytic molecules...
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Fall 2017
This thesis focuses on formulating and analyzing non linear models for microbial dynamics vis-a-vis human and environmental health. Firstly, we develop and investigate a stoichiometric organic matter decomposition model in a chemostat culture that incorporates the dynamics of grazers. This...
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Fall 2016
Understanding human immunodeficiency-1 (HIV-1) replication and latency in different reservoirs is an ongoing challenge in the care of patients with HIV/AIDS. A mathematical model was created that predicted HIV-1 and simian immunodeficiency virus (SIV) infection dynamics within the brain during...
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Mathematical Models and Inverse Algorithms for Childhood Infectious Diseases with Vaccination - Case Studies in Measles
DownloadFall 2014
Children are at a high risk of infection since they have not yet developed mature immunity. Childhood infectious diseases, such as measles, chicken pox and mumps, remain epidemic and endemic around the world. Yet, their dynamics are still not fully understood. SIR-type models have been proposed...
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Fall 2010
Human T-lymphotropic virus type I (HTLV-I) is a persistent human retrovirus characterized by life-long infection and risk of developing HAM/TSP, a progressive neurological and inflammatory disease. Despite extensive studies of HTLV-I, a complete understanding of the viral dynamics has been...