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2014

Owttrim, George W., Tarassova, Oxana S., Chamot, Danuta

Conditional proteolysis is a crucial process regulating the abundance of key regulatory proteins associated with the cell cycle, differentiation pathways, or cellular response to abiotic stress in eukaryotic and prokaryotic organisms. We provide evidence that conditional proteolysis is involved...

2012

Dobrinsky, John, Zhou, Chi, Pasternak, J. Alexander, Dyck, Michael K., Foxcroft, George R., Nieminen, Julie, Tsoi, Stephen, Rigault, Philippe, Sirard, Marc-André, Robert, Claude, Grant, Jason R.

Background The domestic pig is an important livestock species and there is strong interest in the factors that affect the development of viable embryos and offspring in this species. A limited understanding of the molecular mechanisms involved in early embryonic development has inhibited our...

Fall 2009

Paradis, Francois

Pig follicle development is a complex but poorly understood process involving both gonadotrophins and local ovarian factors. A series of studies sought to investigate these intrafollicular cell-to-cell interactions. Microarray analysis combined with gene ontology revealed that the oocyte,...

2016

Godbout, Roseline, Brindley, David N., McMullen, Todd, Mackey, John R., Benesch, Matthew, Mi, Si, Venkatraman, Ganesh, Liu, Rong-Zong, Curtis, Jonathan M., Tang, Xiaoyun, Bekele, Raie T.

Tamoxifen is the accepted therapy for patients with estrogen receptor-α (ERα)-positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or progression on therapy, is frequent and precedes death from metastases. To improve breast cancer treatment it is vital...

2015

Wlodarska, Marta, Bravo, David M., Finlay, B.B., Willling, Benjamin P.

Plant extracts, or phytonutrients, are used in traditional medicine practices as supplements to enhance the immune system and gain resistance to various infectious diseases and are used in animal production as health promoting feed additives. To date, there are no studies that have assessed their...

2000

Kujat, S. L., Owttrim, G. W.

In photosynthetic organisms it is becoming increasingly evident that light-driven shifts in redox potential act as a sensor that initiates alterations in gene expression at both the level of transcription and translation. This report provides evidence that the expression of a cyanobacterial RNA...

2015

Malecki, Irek A., Martin, Graeme B., Cozens, Greg, Hawken, Penelope A.R., Liang, Guanxiang, Guan, Yongjuan, Vercoe, Philip E., Guan, Le Luo

We tested whether reductions in spermatozoal quality induced by under-nutrition are associated with increased germ cell apoptosis and disrupted spermatogenesis, and whether these effects are mediated by small RNAs. Groups of 8 male sheep were fed for a 10% increase or 10% decrease in body mass...

2016

Liu, Jian-Feng, Fan, Ziyao, Li, Junhui, Wang, Jiafu, Wang, Zhiquan, Zhao, Pengju, Kang, Huimin, Zhang, Qin, Yin, Zongjun, Wang, Haifei

In this study, we performed a genome-wide SV detection among the genomes of thirteen pigs from diverse Chinese and European originated breeds by next genetation sequencing, and constrcuted a single-nucleotide resolution map involving 56,930 putative SVs. We firstly identified a SV hotspot...

1997-01-01

Wang, Huayan, Singh, Dyal, Fliegel, Larry

The Na+/H+exchanger is a ubiquitous plasma membrane protein that is responsible for pH regulation and is activated by growth factors. We examined the role of the Na+/H+ exchanger in cell growth and differentiation. Treatment of P19 cells with the Na+/H+ exchanger inhibitor Hoe 694 eliminated...