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Skip to Search Results- 13Cryopreservation
- 4Cryoprotectant agents
- 4Viability
- 4Vitrification
- 3Articular cartilage
- 3Chondrocytes
- 9Chemical and Materials Engineering, Department of
- 9Chemical and Materials Engineering, Department of/Research Articles and Materials (Chemical and Materials Engineering)
- 8Graduate and Postdoctoral Studies (GPS), Faculty of
- 8Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 4Surgery, Department of
- 4Surgery, Department of/Orthopaedic Surgery
- 1Adesida, Adetola B (Surgery)
- 1Elliott, Janet A W (Chemicals and Material Engineering)
- 1Elliott, Janet A. W. (Chemical & Materials Engineering and Laboratory Medicine & Pathology)
- 1Elliott, Janet A.W. (Chemical and Materials Engineering)
- 1Elliott, Janet AW (Chemical and Materials Engineering)
- 1Jomha, Nadr (Surgery)
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Fall 2009
Recent advances in the fundamental theories in cryobiology using thermodynamic principles have created new opportunities for innovative methodologies in cryobiology. This thesis tested the hypothesis that calculated indicators of the two-factor hypothesis of cryoinjury, depending on cellular...
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Characterization of cryobiological responses in TF-1 cells using interrupted freezing procedures
Download2014-09-22
McGann, L. E., Elliott, J. A., Ross-Rodriguez, L. U.
Cryopreservation currently is the only method for long-term preservation of cellular viability and function for uses in cellular therapies. Characterizing the cryobiological response of a cell type is essential in the approach to designing and optimizing cryopreservation protocols. For cells used...
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Cryopreserved amniotic membrane as transplant allograft: viability and post-transplant outcome
Download2015-09-11
Hayward, K., Holovati, J.L. , Mokoena, T., Marquez-Curtis, L.A., Perepelkin, N.M.J., Elliott, J.A.W. , Bentley, M.J., McGann, L.E., Ross-Rodriguez, L.U.
Amniotic membrane (AM) transplantation is increasingly used in ophthalmological and dermatological surgeries to promote re-epithelialization and wound healing. Biologically active cells in the epithelial and stromal layers deliver growth factors and cytokines with anti-inflammatory,...
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2010
Law, G. K., Elliott, J. A., Forbes, J. F., Weiss, A. D., McGann, L. E., Jomha, N. M.
Large articular cartilage defects have proven difficult to treat and often result in osteoarthritis of the affected joint. Cryopreservation of articular cartilage can provide an increased supply of tissues for osteochondral allograft but cryoprotective agents are required; however, few studies...
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2012
Law, G. K., Forbes, J. F., Elliott, J. A., McGann, L. E., Jomha, N. M., Prasad, V., Almansoori, K. A.
Background Vitrification is a method of cryopreservation by which cells and tissues can be preserved at low temperatures using cryoprotective agents (CPAs) at high concentrations (typically ⩾6.0 M) to limit the harmful effects of ice crystals that can form during cooling processes. However, at...
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Determination of Cryoprotectant Behavior, Physiological and Anatomical Characterization of the Porcine Meniscus as a Model for Future Meniscal Vitrification Studies
DownloadSpring 2016
The menisci hold significant, protective biomechanical function in the human knee and loss of meniscal functions have been linked to the development of osteoarthritis. Currently, irreparable or non-salvageable meniscal injuries undergo partial or total removal of injured menisci to alleviate...
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2014
Prasad, V., Laouar, L., Jomha, N. M., McGann, L. E., Fahmy, M. D., Almansoori, K. A., Elliott, J. A.
Vitrification of articular cartilage (AC) could enhance tissue availability but requires high concentrations of cyroprotective agents (CPAs). This study investigated relative injuries caused by commonly used CPAs. We hypothesized that the in situ chondrocyte dose–injury relationships of five...
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Fall 2014
This thesis develops three major essays on Arbitrage Theory, Market’s Viabil- ity and Informational Markets. The first essay (Chapter 3) elaborates the exact connections among the No-Unbounded-Profit-with-Bounded-Risk (called NUPBR hereafter) condition, the existence of the numeraire portfolio,...
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Investigating cryoinjury using simulations and experiments: 1. TF-1 cells during two-step freezing (rapid cooling interrupted with a hold time)
Download2014-09-22
McGann, L. E., Ross-Rodriguez, L. U., Elliott, J. A.
There is significant interest in designing a cryopreservation protocol for hematopoietic stem cells (HSC) which does not rely on dimethyl sulfoxide (Me2SO) as a cryoprotectant. Computer simulations that describe cellular osmotic responses during cooling and warming can be used to optimize the...