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Spring 2021
While PrP is almost always found in the glycosylated state, there has been very little study attempting to explore the effects of the size of glycans, the composition of glycans, and the site of glycosylation on the stability of PrP. These effects can potentially play an important role in the...
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Transcriptomic analysis of zebrafish prion protein mutants supports conserved cross-species function of the cellular prion protein; and zebrafish as a model for cisplatin induced ototoxicity and transition metals as potential ligands for Tlr4ba and Tlr4bb
DownloadFall 2021
The work presented in this thesis is split between two projects. The first utilises prp1 and prp2 knockout zebrafish to investigate physiological functions of the cellular prion protein (PrPC). The second builds upon the use of zebrafish as a model for hearing loss to confirm a role of toll-like...
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SLC4A11 in Blinding Endothelial Corneal Dystrophies: Characterization, Molecular Defect and Potential Therapeutic Strategy
DownloadFall 2019
Endothelial Corneal Dystrophies (ECD), genetic blinding diseases with a heterogeneous pathophysiology, are the leading cause of endothelial keratopathy (corneal transplants). Patients manifest symptoms, including corneal edema with increased corneal thickness and loss of corneal endothelial cells...
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Electrocoalescence of Water Droplets in Oil Emulsions: Effect of Electric Fields, Surfactants, and Chemical Demulsifiers
DownloadSpring 2019
Stabilization of water-in-oil droplets during bitumen extraction and refining process poses a major challenge in the oil sands industry. These crude oil emulsions are stabilized by rigid films at water droplet-oil interfaces. The salty water remaining in oil causes equipment corrosion, catalyst...
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Spring 2019
A bacterial colony constitutes a complex microcosm which is equipped with a wide range of defensive adaptations that allow the colony to survive adverse environmental conditions and predation. The extreme resilience of bacteria in colonies has been a subject of continued research for nearly two...
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Bacterial stimulation of lipid vesicle production in green microalga Dunaliella tertiolecta
DownloadFall 2019
Algae and bacteria form complex interactions through the exchange of bioactive molecules and nutrients. A wide range of phenotypes, and often their very survival, are influenced by these chemically mediated relationships, shaping the ecology and diversity of marine communities. Here we sought to...
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Spring 2018
Graphene has created much excitement in the scientific community since 2004, when Novoselov and Geim developed a method to exfoliate atomic layers from graphite, earning them the 2010 Nobel prize. The great interest in graphene stems from its outstanding material properties such as atomic...
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Development and Analysis of Magnetic Carbon Nanotube and Microbubble-Assisted High Centrifugation Field Techniques For The Increase of Cell Membrane Permeability
DownloadSpring 2014
To cure diseases at the gene level, therapeutic biomaterials need to enter the cells. However, since the cell membrane is a highly selective structure, its permeability is usually very low. In this thesis, we propose two innovative and efficient methods to increase cell membrane permeability....
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Interactions Between Host Trees, Bacteria, and Fungi: Impacts on Mountain Pine Beetle (Dendroctonus ponderosae) Reproduction
DownloadFall 2012
Warming winter trends due to climate change have allowed for a range expansion of the mountain pine beetle, and the beetle now threatens Canada’s economically and ecologically important jack pine forests. The beetle’s success in jack pine trees will depend upon successful colonization of the...