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- 4Cryoprotectant agents
- 3Activation energy
- 3Cryopreservation
- 2Articular cartilage
- 2Chondrocytes
- 6Graduate and Postdoctoral Studies (GPS), Faculty of
- 6Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 3Chemical and Materials Engineering, Department of
- 3Chemical and Materials Engineering, Department of/Research Articles and Materials (Chemical and Materials Engineering)
- 3Surgery, Department of
- 3Surgery, Department of/Orthopaedic Surgery
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2010
Law, G. K., Elliott, J. A., Forbes, J. F., Weiss, A. D., McGann, L. E., Jomha, N. M.
Large articular cartilage defects have proven difficult to treat and often result in osteoarthritis of the affected joint. Cryopreservation of articular cartilage can provide an increased supply of tissues for osteochondral allograft but cryoprotective agents are required; however, few studies...
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2012
Law, G. K., Forbes, J. F., Elliott, J. A., McGann, L. E., Jomha, N. M., Prasad, V., Almansoori, K. A.
Background Vitrification is a method of cryopreservation by which cells and tissues can be preserved at low temperatures using cryoprotective agents (CPAs) at high concentrations (typically ⩾6.0 M) to limit the harmful effects of ice crystals that can form during cooling processes. However, at...
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Deformation Transitions and their Effects on the Long-term Performance of Polyethylene and its Pressure Pipe
DownloadFall 2021
Ductile-to-brittle (DB) transition is of tremendous importance for lifetime prediction of polyethylene (PE). Majority of current methods for determining critical stress for the DB transition of PE products use notched coupon specimens in order to shorten the test timeframe. However, those work...
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Determination of Cryoprotectant Behavior, Physiological and Anatomical Characterization of the Porcine Meniscus as a Model for Future Meniscal Vitrification Studies
DownloadSpring 2016
The menisci hold significant, protective biomechanical function in the human knee and loss of meniscal functions have been linked to the development of osteoarthritis. Currently, irreparable or non-salvageable meniscal injuries undergo partial or total removal of injured menisci to alleviate...
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1988
Plastow, G. S., Mileham, A. J., Siggens, K. W.
A 3.8 kb male specific fragment was observed following agarose gel etectrophoresis of porcine DNA digested with Sph I. DNA was recovered from this region of a gel using DE-81 paper and ligated to Sph I digested pUC18. Plasmids carrying male specific sequences were identified by their differential...
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Fall 2009
Islet transplantation has the potential to be an effective treatment for patients with type 1 diabetes. However, a shortage of human donor islets and the need for continuous immunosuppressive therapy currently limit this therapy to patients with brittle type 1 diabetes. Neonatal pigs may...
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2014-09-26
Rekieh, K., Abazari, A., Elliott, J.A., Jomha, N.M., Law, G.K., McGann, L.E.
Objective: Osteochondral allografting is an effective method to treat large osteochondral defects but difficulties in tissue preservation have significantly limited the application of this technique. Successful cryopreservation of articular cartilage (AC) could improve the clinical availability...
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Spring 2011
The Kim and Chan experiment in 2004 gave the first experimental evidence of a possible supersolid state. Even though the origin of this state is not clear yet, several experimental and theoretical investigations suggest defects are responsible for this curious phase. We have used heat pulses and...
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Spring 2013
Early embryonic development is a dynamic period that requires precise and timely interaction between the developing embryo and the maternal environment. A series of studies were carried out in order to identify the vital components of this environment and to understand their temporal and spatial...