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Skip to Search Results- 3Cairo, Christopher W.
- 3Hunter, Carmanah D
- 3Richards, Michele R
- 2Guo, Tianlin
- 1Darestani, Reza Rezaei
- 1Daskhan, Gour
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Human neuraminidase isoenzymes show variable activities for 9-O-acetyl-sialoside substrates
Download2018-01-16
Hunter, Carmanah D, Khanna, Neha, Richards, Michele R, Darestani, Reza Rezaei, Zou, Chunxia, Klassen, John S, Cairo, Christopher W.
Recognition of terminal sialic acids is central to many cellular processes, and structural modification of sialic acid can disrupt these interactions. A prominent, naturally occuring, modification of sialic acid is 9-O-acetylation (9-O-Ac). Study of this modification through generation and...
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Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivity
Download2018-05-16
Richards, Michele R, Guo, Tianlin, Hunter, Carmanah D, Cairo, Christopher W.
Inhibitors of viral neuraminidase enzymes have been previously developed as therapeutics. Humans can express multiple forms of neuraminidase enzymes (NEU1, NEU2, NEU3, NEU4) that share a similar active site and enzymatic mechanism with their viral counterparts. Using a panel of purified human...
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2018-05-24
Hunter, Carmanah D, Guo, Tianlin, Daskhan, Gour, Richards, Michele R, Cairo, Christopher W.
The plasma membrane of cells contains a diverse array of lipids that provide important structural and biological features. Glycolipids are typically a minor component of the cell membrane and consist primarily of glycosphingolipids (GSLs). GSLs in vertebrates contain a multifarious assortment of...