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Skip to Search Results- 20Plastow, Graham S.
- 10Harding, John C. S.
- 10Stothard, Paul
- 9Bao, Hua
- 9Lunney, Joan K.
- 8Dekkers, Jack C. M.
- 15PigGen Canada
- 15PigGen Canada/Journal Articles
- 9Roy Berg Kinsella Research Ranch
- 9Roy Berg Kinsella Research Ranch/Journal Articles (Kinsella Ranch)
- 3Agricultural, Food and Nutritional Science, Department of
- 3Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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Genome-wide analysis of the transcriptional response to porcine reproductive and respiratory syndrome virus infection at the maternal/fetal interface and in the fetus
Download2016
Ladinig, Andrea, Stothard, Paul, Bao, Hua, Hong, Linjun, Lunney, Joan K., Harding, John C. S., Wilkinson, Jamie M., Plastow, Graham S.
Background Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant pigs can result in congenital infection and ultimately fetal death. Little is known about immune responses to infection at the maternal-fetal interface and in the fetus itself, or the molecular events...
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Genome-wide analysis of thetranscriptional response to porcinereproductive and respiratory syndromevirus infection at the maternal/fetalinterface and in the fetus
Download2016-01-01
Wilkinson, Jamie M., Bao, Hua, Ladinig, Andrea, Hong, Linjun, Stothard, Paul, Lunney, Joan K., Plastow, Graham S., Harding, John C. S.
Background:Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant pigs can result incongenital infection and ultimately fetal death. Little is known about immune responses to infection at thematernal-fetal interface and in the fetus itself, or the molecular events...
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Genome-wide whole blood microRNAome and transcriptome analyses revealed miRNA-mRNA regulated host response to foodborne pathogen Salmonella infection in swine
Download2015-07-31
Arantes, Adriano S., Tuggle, Christopher K., Guan, Le L., Bearson, Shawn M.D., Sun, Xu, Plastow, Graham S., Kommadath, Arun, Bao, Hua, Stothard, Paul, Liang, Guanxiang
To understand the role of miRNAs in regulating genes involved in host response to bacterial infection and shedding of foodborne pathogens, a systematic profiling of miRNAs and mRNAs from the whole blood of pigs upon Salmonella challenge was performed. A total of 62 miRNAs were differentially...
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Genomic Analysis of IgG Antibody Response to Common Pathogens in Commercial Sows in Health-Challenged Herds
Download2020-10-23
Sanglard, Leticia P., PigGen Canada, Mote, Benny E., Willson, Philip, Harding, John C. S., Plastow, Graham S., Dekkers, Jack C. M., Serao, Nick V. L.
Losses due to infectious diseases are one of the main factors affecting productivity in the swine industry, motivating the investigation of disease resilience-related traits for genetic selection. However, these traits are not expected to be expressed in the nucleus herds, where selection is...
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Kinome profiling of peripheral blood mononuclear cells collected prior to vaccination reveals biomarkers and potential mechanisms of vaccine unresponsiveness in pigs
Download2020-12-01
Lipsit, Sean W. L., Wilkinson, James, Scruten, Erin, Facciuolo, Antonio, Denomy, Connor, Griebel, Philip J., Kusalik, Anthony, Plastow, Graham, Napper, Scott
Inter-individual variance in host immune responses following vaccination can result in failure to develop protective immunity leaving individuals at risk for infection in addition to compromising herd immunity. While developing more efficacious vaccines is one strategy to mitigate this problem,...
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Maternal and fetal predictors of fetal viral load and death in third trimester, type 2 porcine reproductive and respiratory syndrome virus infected pregnant gilts
Download2015-09-25
Wilkinson, Jamie M., Lunney, Joan K., Detmer, Susan E., Ladinig, Andrea, Harding, John C.S., Ashley, Carolyn, Plastow, Graham
Minimal research has focused on understanding mechanisms underlying porcine reproductive and respiratory syndrome virus (PRRSV) induced reproductive failure. We have completed a large-scale project investigating phenotypic and genotypic predictors of reproductive PRRS severity in which numerous...
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Novel Resilience Phenotypes Using Feed Intake Data From a Natural Disease Challenge Model in Wean-to-Finish Pigs
Download2019-01-01
Putz, Austin M., Harding, John C. S., Dyck, Michael K., Fortin, F., Plastow, Graham S., Dekkers, Jack C. M., PigGen Canada
The objective of this study was to extract novel phenotypes related to disease resilience using daily feed intake data from growing pigs under a multifactorial natural disease challenge that was designed to mimic a commercial environment with high disease pressure to maximize expression of...
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Pathologic Evaluation of Type 2 PorcineReproductive and Respiratory SyndromeVirus Infection at the Maternal-FetalInterface of Late Gestation Pregnant Gilts
Download2016-03-10
Novakovic, Predrag, Harding, John C. S., Al-Dissi, Ahmad, Ladinig, Andrea, Detmer, Susan E.
The pathogenesis of fetal death caused by porcine reproductive and respiratory syndromevirus (PRRSV) remains unclear. The objective of this study was to improve our understand-ing of the pathogenesis by assessing potential relationships between specific histopatho-logical lesions and PRRSV RNA...
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Potential regulatory role of microRNAs in the development of bovine gastrointestinal tract during early life
Download2014
Liang, Guanxiang, Bao, Hua, Guan, Leluo, Griebel, Philip J., Stothard, Paul, McFadden, Thomas B., Malmuthuge, Nilusha
This study aimed to investigate the potential regulatory role of miRNAs in the development of gastrointestinal tract (GIT) during the early life of dairy calves. Rumen and small intestinal (mid-jejunum and ileum) tissue samples were collected from newborn (30 min after birth; n = 3), 7-day-old...