Search

2007

Guan, L., Guo, Y., Liu, T., Li, H., Wang, J., Zheng, W.M., Wong, G.K.

Background The main two sorts of automatic gene annotation frameworks are ab initio and alignment-based, the latter splitting into two sub-groups. The first group is used for intra-species alignments, among which are successful ones with high specificity and speed. The other group contains more...

2012

Xia, Y., Zhang, X., Mu, Z., Li, X., Wang, T., Qu, J., Chen, H., Li, K., Zhu, L., Wang, L., Liu, Y., Zhang, K., Guan, J., Wu, H., Jiang, A., Yin, G., Xi, D., Shuai, S., Lang, Q., Jiang, Y., Wang, Z., Luo, Z., Xiao, H., Li, Y., Huang, S., Gu, Y., Beck, S., Ma, J., Wang, H., Jing, L., Plastow, G. S., Jiang, Z., Gao, X., Chen, L., Tang, G., Wang, J., Li,R., Li, M., Mai, M., Wang, Y., Wang, X., Zhong, Z., Nie, J., Zhou, S., Yang, H., Yi, N., Li, N.

It is evident that epigenetic factors, especially DNA methylation, have essential roles in obesity development. Here, using pig as a model, we investigate the systematic association between DNA methylation and obesity. We sample eight variant adipose and two distinct skeletal muscle tissues from...

2004

Wang, J., Chen, Y., Zhao, H., Dai, M., Zhao, W., Huang, X., Zhang, Y., Ren. X., Jiao, Y., Wong, G., Wei, S., Ni, P., Yu, J., Zhang, J., Li, S., Yang, H., Fu, J., He, X.

Rice is a major food staple for the world's population and serves as a model species in cereal genome research. The Beijing Genomics Institute (BGI) has long been devoting itself to sequencing, information analysis and biological research of the rice and other crop genomes. In order to facilitate...

2005

Li, S., Dai, M., He, X., Zhang, Y., Ruan, J., Burt, D., Yu, J., Wang, J., Yang, H., Hu, Y., Liu, B., Wong, G., Ye, C., Chen, J., Cong, L., Fang, L.

Working in parallel with the efforts to sequence the chicken (Gallus gallus) genome, the Beijing Genomics Institute led an international team of scientists from China, USA, UK, Sweden, The Netherlands and Germany to map extensive DNA sequence variation throughout the chicken genome by sampling...

2008

Li, R., Wang, J., Wong, G.K.S., Zheng, H., Xu, S., Clark, T., Zheng, X., Vang, S.

Background Gene conversion causes a non-reciprocal transfer of genetic information between similar sequences. Gene conversion can both homogenize genes and recruit point mutations thereby shaping the evolution of multigene families. In the rice genome, the large number of duplicated genes...

2006

Wang, W., Li, J., Liu, D., Lu, Z., Zheng, H., Wong, G., Cai, Z., Fan, C., Zhang, J., Vang, S., Long, M., Zhang, G., Wang, J., Shi, J.

Retroposition is widely found to play essential roles in origination of new mammalian and other animal genes. However, the scarcity of retrogenes in plants has led to the assumption that plant genomes rarely evolve new gene duplicates by retroposition, despite abundant retrotransposons in plants...

2007

Wang, W., Wang, H., Wong, G.K.S., Zheng, H., Clark, T., Zhang, G., Kang, L., Wang, J., Shi, J., Wang, X.

Background Insects constitute the vast majority of known species with their importance including biodiversity, agricultural, and human health concerns. It is likely that the successful adaptation of the Insecta clade depends on specific components in its proteome that give rise to specialized...

2005

Gorodkin, J., Christensen, O. F., Jørgensen, F. G., Yang, H., Bendixen, C., Brunak, S., Wernersson, R., Panitz, F., Hornshøj, H., Mailund, T., Wong, G.K.S., Dong, W., Wang, J., Li, W., Klein, A., Fredholm, M., Hu, S., Stærfeldt, H.-H., Bolund, L., Liu, B., Schierup, M. H., Yu, J.

Background Comparative whole genome analysis of Mammalia can benefit from the addition of more species. The pig is an obvious choice due to its economic and medical importance as well as its evolutionary position in the artiodactyls. Results We have generated ~3.84 million shotgun sequences...

2005

Ye, C., Wang, J., Li, S., Li, R., Wong, G.K.S., Ye, J., Yang, H., Han, Y., Yu, J.

We describe an algorithm, ReAS, to recover ancestral sequences for transposable elements (TEs) from the unassembled reads of a whole genome shotgun. The main assumptions are that these TEs must exist at high copy numbers across the genome and must not be so old that they are no longer...

2008

O'Sullivan, N.P., Wong, G.K., Lawley, C.T., McKay, J.C., Groenen, M.A., Fulton, J.E., Crooijmans, R.P., Muir, W.M., Megens, H.J., Cheng, H.H., McLeod, S., Zhang, H.M., Zhang, Y., Albers, G.A.A., Delany, M.E., Settar, P., Okimoto, R., Vereijken, A., Wang, J., Jungerius-Rattink, A.

In 2004 the chicken genome sequence and more than 2.8 million single nucleotide polymorphisms (SNPs) were reported. This information greatly enhanced the ability of poultry scientists to understand chicken biology, especially with respect to identification of quantitative trait loci (QTL) and...