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2014/22/2014

Prickett, R. C., McGann, L. E., Elliott, J. A., Hakda, S.

A non-ideal osmotic equilibrium equation is proposed as a replacement for the Boyle van’t Hoff equation to describe the equilibrium volume of a living cell as a function of external osmolality. Contrary to common understanding, the Boyle van’t Hoff equation is only valid for ideal, dilute...

2014-09-22

McGann, L. E., Elliott, J. A., Ross-Rodriguez, L. U.

Cryopreservation currently is the only method for long-term preservation of cellular viability and function for uses in cellular therapies. Characterizing the cryobiological response of a cell type is essential in the approach to designing and optimizing cryopreservation protocols. For cells used...

2014-09-22

McGann, L. E., Ross-Rodriguez, L. U., Elliott, J. A.

There is significant interest in designing a cryopreservation protocol for hematopoietic stem cells (HSC) which does not rely on dimethyl sulfoxide (Me2SO) as a cryoprotectant. Computer simulations that describe cellular osmotic responses during cooling and warming can be used to optimize the...

2014-11-01

Sowa, Barbara, Zhang, Xuehua, Kozielski, Karen A., Dunstan, Dave E., Hartley, Patrick G., Maeda, Nobuo

We recently reported the development of a high pressure electrical conductivity probe (HP-ECP) for experimental studies of formation of gas hydrates from electrolytes. The onset of the formation of methane-propane mixed gas hydrate from salt solutions was marked by a temporary upward spike in the...

2014

Prasad, V., Laouar, L., Jomha, N. M., McGann, L. E., Fahmy, M. D., Almansoori, K. A., Elliott, J. A.

Vitrification of articular cartilage (AC) could enhance tissue availability but requires high concentrations of cyroprotective agents (CPAs). This study investigated relative injuries caused by commonly used CPAs. We hypothesized that the in situ chondrocyte dose–injury relationships of five...

2014-10-08

McGann, L.E., Elliott, J.A., Law, G.K., Abazari, A., Jomha, N.M.

Some minor errors in our published manuscript need to be addressed

2014-01-01

Ma, Aijing, Xu, Jie, Zhang, Xuehua, Zhang, Bin, Wang, Dayang, Xu, Haolan

Interfacial nanodroplets were grafted to the surfaces of self-sacrificed template particles in a galvanic reaction system to assist the construction of 3D Au porous structures. The interfacial nanodroplets were formed via direct adsorption of surfactant-free emulsions onto the particle surfaces....

2014-09-26

Rekieh, K., Abazari, A., Elliott, J.A., Jomha, N.M., Law, G.K., McGann, L.E.

Objective: Osteochondral allografting is an effective method to treat large osteochondral defects but difficulties in tissue preservation have significantly limited the application of this technique. Successful cryopreservation of articular cartilage (AC) could improve the clinical availability...

2014-09-22

McGann, L.E., Ross-Rodriguez, L.U., Elliott, J.A.

Cryopreservation plays a key role in the long-term storage of native and engineered cells and tissues for research and clinical applications. The survival of cells and tissues after freezing and thawing depends on the ability of the cells to withstand a variety of stresses imposed by the...

2015-06-01

Zhang, Xuehua, Crivoi, Alexandru, Duan, Fei

Experimental atomic force microscopy (AFM) images show the dried-in patterns from amino acid solutions which can be in the form of dots or networks. The three-dimensional lattice-gas Kinetic Monte Carlo (KMC) model is applied to simulate the formation of dot-like and network-like particle...