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Optimization, adaptation and application of protein misfolding cyclic amplification to detection of prions in blood plasma
DownloadFall 2010
The PMCA assay was optimized for adaptation to low level detection of PrPSc in hamster plasma. Evaluation of numerous key variables of the PMCA assay led to an optimized protocol capable of ~3 log10 amplification after 32 cycles (two 16 hour rounds). When commercially purchased normal hamster...
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Fall 2010
In this thesis, we develop some new models and efficient algorithms for image denoising. The total variation model of Rudin, Osher, and Fatemi(ROF) for image denoising is considered to be one of the most successful deterministic denoising models. It exploits the non-smooth total variation (TV)...
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Fall 2011
This thesis studies the reinforcement learning and planning problems that are modeled by a discounted Markov Decision Process (MDP) with a large state space and finite action space. We follow the value-based approach in which a function approximator is used to estimate the optimal value function....
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Spring 2011
Large corporations have a significant amount of working capital tied into the acquisition and storage of spare parts. In the industry, spare parts inventory policies and strategies are often developed in isolation from reliability centered maintenance practices – this results in significant...
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Fall 2011
Recently, Wireless Sensor Networks (WSNs) have been used in many monitoring applications, e.g., environment monitoring. A WSN consists of a set of nodes, each having one or more sensors to measure a phenomena. Nodes are connected to each other using wireless radio communications. Typically, there...
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Spring 2011
This research investigates and proposes methods to be used for the automation of the conceptual design phases of variational mechanisms. It employs the concept of feature-based modeling approaches. A method is proposed for integrating the dimensional synthesis, mechanical design and CAD...
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Fall 2011
High efficiency and low NOx emissions make Homogeneous Charge Compression Ignition (HCCI) promising for use in internal combustion engines. Combining HCCI with Spark Ignition (SI) allows for extension of the engine’s operating range. A Physics-based Mode Switch Model (PMSM) of SI-HCCI mode...
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Fall 2011
Currently, the Cross Cancer Institute uses CT imaging in conjunction with the traditional Manchester system, which prescribes dose to a defined point, for cervix cancer brachytherapy. To take advantage of MRI for enhanced definition of soft tissue including the cancerous tissue itself, this...
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Fall 2011
The imbalanced learning problem occurs in a large number of economic and health domains of great importance; consequently, it has drawn a significant amount of interest from academia, industry, and government funding agencies. Several researchers have used stratification to alleviate this...
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Spring 2011
Standard survival analysis focuses on population-based studies. The objective of our work, survival prediction, is different: to find the most accurate model for predicting the survival times for each individual patient. We view this as a regression problem, where we try to map the features for...