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Skip to Search Results- 2Guan, Leluo
- 2Jin, Weiwu
- 1Abbasi Dezfouli, Meysam
- 1Ambrose, Divakar J.
- 1Beaudoin, Frédéric
- 1Beaulieu, Michael J.
- 7Graduate and Postdoctoral Studies (GPS), Faculty of
- 7Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 4Agricultural, Food and Nutritional Science, Department of
- 4Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 1Chemistry, Department of
- 1Chemistry, Department of/Journal Articles (Chemistry)
- 1Co-supervisor: Dr. Marc Mackenzie (Oncology)
- 1Damaraju, Sambasivarao (Medical Sciences - Laboratory Medicine and Pathology)
- 1Davis, Faith (School of Public Health)
- 1Dr. Changxi Li (Agricultural, Food & Nutritional Science)
- 1Guan, Leluo (Department of Agricultural, Food, and Nutritional Science, University of Alberta)
- 1Hatcher, Juanita (School of Public Health)
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Brain fatty acid-binding protein and ω-3/ω-6 fatty acids: Mechanistic insight into the poor prognosis of malignant glioma cell migration
Download2010
Godbout, Roseline, Mita, Raja, Field, Catherine J., Beaulieu, Michael J.
Malignant gliomas (MG) are highly infiltrative tumors that consistently recur despite aggressive treatment. Brain fatty acid-binding protein (FABP7), which binds docosahexaenoic acid (DHA) and arachidonic acid (AA), localizes to sites of tumor infiltration and is associated with a poor prognosis...
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Fall 2015
There is a concern that brain tumours are underreported in the Alberta Cancer Registry (ACR), yet no studies have been performed to investigate this issue. This study addresses the concern of underreporting of brain tumours in the ACR by assessing case ascertainment of primary brain tumours cases...
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Drug Resistance in Breast Cancer: Characterization of Rationally Designed Paclitaxel Analogs in Model Systems
DownloadFall 2013
Breast cancer is a leading cause of cancer related deaths among women in the developed world. Treatment options for breast cancer include taxanes, which mediate cytotoxic effects by inducing microtubule polymerization which impedes cell division. Taxane resistant breast cancer is a mounting...
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Spring 2014
Adipose tissue plays an important role in the energetic balance, but it is also an important aspect of meat quality and animal productivity. However, the understanding on how fat metabolism is regulated in beef cattle is not clear. This research aimed at exploring how bovine adipose tissue is...
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Hsp90 and its co-chaperones regulate the activity of human Argonaute2 in RNA-mediated silencing pathways
DownloadFall 2011
The potent ability of small, double-stranded RNAs to silence gene expression was initially reported 1998, sparking revolutions in molecular biology and genetics. Since then, intensive research into the mechanism of RNA-mediated silencing has implicated the machinery of this pathway in the...
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Identification of functional genes for feed efficiency traits via transcriptome analyses to enhance the genomic prediction accuracy in beef cattle
DownloadFall 2019
Residual feed intake (RFI), a measure of feed efficiency, and its component traits including average daily gain (ADG), dry matter intake (DMI) and metabolic weight (MWT) are traits of great economic importance to the beef industry. The genetic improvement of these traits can improve the...
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Fall 2013
Intrafractional tumour tracking is of considerable interest as a means to minimize the PTV in treating mobile tumours. By utilizing the intrafractional MR imaging feature of linac-MR, this thesis seeks to develop a direct, non-surrogate based intrafractional tumour tracking system, and physically...
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Lipid Modified Polymers for Transfection of Human CRL Fibroblasts, and for siRNA Mediated MDR Reversal in Melanoma Cancer Therapy
DownloadFall 2010
Gene delivery for therapeutic purposes is quickly emerging as the best potential treatment option for inherited genetic diseases and cancer. Viral gene carriers have been the choice for this purpose due to their high efficiency, but harmful immunogenic and oncogenic host reactions have limited...
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2014
Jin, Weiwu, He, Maolong, Guan, Leluo, Romao, Josue M., McAllister, Tim
Background MicroRNAs (miRNAs) are small non-coding RNAs found to regulate several biological processes including adipogenesis. Understanding adipose tissue regulation is critical for beef cattle as fat is an important determinant of beef quality and nutrient value. This study analyzed the...
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2008
Ambrose, Divakar J., Emmanuel, Daya G. V.
Abstract — An 8-month-old, virgin Holstein heifer with precocious mammary development was presented for examination. Protein, fat, and lactose in the mammary secretion were 14.90%, 0.12%, and 0.20%, respectively; somatic cell count was 3.9 3 10 6 /mL, with no bacterial infection. The heifer was...