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Skip to Search Results- 1Adam, Ibrahim S. Y.
- 1Arefanian, Hossein
- 1Bayrack, Kevin R
- 1Chow, Aaron K.Y.
- 1Ellis, Cara E
- 1Fraser, Alastair
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Fall 2009
Islet transplantation has the potential to be an effective treatment for patients with type 1 diabetes. However, a shortage of human donor islets and the need for continuous immunosuppressive therapy currently limit this therapy to patients with brittle type 1 diabetes. Neonatal pigs may...
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Nanophotonic detection of nanomechanical structures for use toward mass sensing applications
DownloadSpring 2014
Nanomechanical beam resonators show much promise for use in integrated on-chip mass sensing systems. This follows from their own very small masses and also their ability to store the mechanical energy of their oscillations to produce strong measurable mechanical response signals. To achieve...
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Fall 2016
Background: NK cells are a key cellular component of antibody-mediated rejection (ABMR), but their role in ABMR has not been identified. We postulated that NK cells are stimulated through their CD16a antibody receptors by donor-specific anti-HLA antibodies in ABMR. There is currently no direct...
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Fall 2018
Ghoraishi Kahangi, Maryam Sadat
Due to their ability to measure extremely small displacements and forces, nanomechanical cantilevers have attracted considerable attention from numerous scientific communities, each exploring a variety of applications. Though typically operated in either vacuum or air, operation of the device in...
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Spring 2011
Several obstacles to widespread use of bacteriocins in food have been identified, including lack of specific, rapid quantitation methods, and little data on their efficacy in food systems. The first objective of this study was to develop a specific, rapid quantitation method for bacteriocins...
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Study of Non-Covalent Protein-Carbohydrate Interactions by Nanoelectrospray Ionization Mass Spectrometry and Surface Plasmon Resonance
DownloadFall 2015
This thesis describes the application of electrospray ionization mass spectrometry (ESI-MS) techniques to identify and quantify antibody-antigen interactions in vitro. Also potential application of nanodiscs (ND) as membrane model in ESI-MS and surface plasmon resonance (SPR) spectroscopy has...
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The potential of novel small inhibitory molecules to prevent the rejection of neonatal porcine islets in mice
DownloadFall 2011
The objectives of this study were to determine the effect of small inhibitory molecules suramin and DR80 on T cell proliferation in vitro as well as in vivo by preventing the rejection of neonatal porcine islets (NPI) in mice when combined with anti-LFA-1 monoclonal antibody (mAb). Suramin and...
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Tolerance to neonatal porcine islet xenografts induced by a combination of monoclonal antibodies
DownloadFall 2009
Islet transplantation is a more physiological way to treat type 1 diabetes. However, shortage of donor tissue and chronic administration of immune suppressive drugs has limited the widespread application of this therapy for all patients with type 1 diabetes, particularly children suffering from...
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Fall 2015
The development of the Edmonton protocol was an important milestone in the process of establishing islet transplantation as a cure for diabetes. However, many challenges must still be overcome, including the shortage of donor organs. To address this issue, we believe that neonatal porcine islets...