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Skip to Search Results- 17Harding, John C. S.
- 15Plastow, Graham S.
- 11Lunney, Joan K.
- 9Bao, Hua
- 9Dekkers, Jack C. M.
- 9Stothard, Paul
- 5PRRS Virus
- 5Pig
- 4PRRSV
- 3Fetal death
- 3Gene expression
- 3Porcine reproductive and respiratory syndrome
- 21PigGen Canada
- 21PigGen Canada/Journal Articles
- 4Agricultural, Food and Nutritional Science, Department of
- 4Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 4Roy Berg Kinsella Research Ranch
- 4Roy Berg Kinsella Research Ranch/Journal Articles (Kinsella Ranch)
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Potential regulatory role of microRNAs in the development of bovine gastrointestinal tract during early life
Download2014
Liang, Guanxiang, Bao, Hua, Guan, Leluo, Griebel, Philip J., Stothard, Paul, McFadden, Thomas B., Malmuthuge, Nilusha
This study aimed to investigate the potential regulatory role of miRNAs in the development of gastrointestinal tract (GIT) during the early life of dairy calves. Rumen and small intestinal (mid-jejunum and ileum) tissue samples were collected from newborn (30 min after birth; n = 3), 7-day-old...
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Putting the microbiota to work: Epigenetic effects of early life antibiotic treatment are associated with immune-related pathways and reduced epithelial necrosis following Salmonella Typhimurium challenge in vitro
Download2020-04-01
Costa, Matheus O., Fouhse, Janelle, Silva, Ana Paula P., Wiling, Benjamin, Harding, John C. S.
Salmonella enterica serovar Typhimurium is an animal welfare and public health concern due to its ability to parasite livestock and potentially contaminate pork products. To reduce Salmonella shedding and the risk of pork contamination, antibiotic therapy is used and can contribute to...
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Relationships of CD163 and CD169 positive cell numbers in the endometrium and fetal placenta with type 2 PRRSV RNA concentration in fetal thymus
Download2016-08-05
Novakovic, Predrag, Harding, John C. S., Ladning, Andrea, Al-Dissi, Ahmad N., MacPhee, Daniel J., Detmer, Susan E.
Several routes of porcine reproductive and respiratory virus PRRSV transmission across the porcine diffuse epitheliochorial placentation have been proposed, but none have been proven. The objectives of this study were to investigate associations between numbers of CD163 and CD169 positive...
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RESEARCHOpen AccessDevelopment of a 3D printed device tosupport long term intestinal culture as analternative to hyperoxic chamber methods
Download2017-01-01
Costa, Matheus O., Nosach, Roman, Harding, John C. S.
Background:Most interactions between pathogenic microorganisms and their target host occur on mucosal surfaces of internal organs such as the intestine. In vitro organ culture (IVOC) provides an unique tool for studyinghost-pathogen interactions in a controlled environment. However, this...
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Fall 2016
Evidence is accumulating regarding the potential long-term impact of the early gut microbiota on host health. However, our current understanding of the early microbiome of cattle, a domestic livestock species that plays an important role in meeting the increasing demand for high quality protein,...
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2019-01-01
Lim, Kyu-Sang, Dong, Qian, Moll, Pamela, Vitkovska, Jana, Wiktorin, Gregor, Bannister, Stephanie, Daujotyte, Dalia, Tuggle, Christopher K., Lunney, Joan K., Plastow, Graham S., Dekkers, Jack C. M.
Background:Gene expression profiling in blood is a potential source of biomarkers to evaluate or predict phenotypic differences between pigs but is expensive and inefficient because of the high abundance of globin mRNA in porcine blood. These limitations can be overcome by the use of QuantSeq...
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The genetic basis of natural antibody titersof young healthy pigs and relationshipswith disease resilience
Download2020-01-01
Chen, Yulu, Tibbs Cortes, Laura E., Ashley, Carolyn, Putz, Austin M., Lim, Kyu-Sang, Dyck, Michael K., Fortin, Frederic, Plastow, Graham S., Dekkers, Jack C. M., Harding, John C. S., PigGen Canada
Background Disease resilience is the ability to maintain performance under pathogen exposure but is difficult to select for because breeding populations are raised under high health. Selection for resilience requires a trait that is heritable, easy to measure on healthy animals, and genetically...
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The gut microbiome and its potential role in the development and function of newborn calf gastrointestinal tract
Download2015
Grebiel, Philip J., Malmuthuge, Nilusha, Guan, Leluo
A diverse microbial population colonizes the sterile mammalian gastrointestinal tract during and after the birth. There is increasing evidence that this complex microbiome plays a crucial role in the development of the mucosal immune system and influences newborn health. Microbial colonization is...
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Type 2 porcine reproductive and respiratory syndrome virus infection increases apoptosis at the maternal-fetal interface in late gestation pregnant gilts
Download2017-03-01
Novakovic, Predrag, Harding, John C. S., Al-Dissi, Ahmad N., Detmer, Susan E.
The pathogenesis of fetal death associated with porcine reproductive and respiratory syndrome (PRRS) is hypothesized to be a consequence of PRRS virus-induced apoptosis at the maternal-fetal interface (MFI). The objectives of this study were to evaluate distribution and degree of apoptosis in the...