Platelet-associated angiogenesis regulating factors: a pharmacological perspective

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  • Platelets, in addition to maintaining hemostasis, also stimulate angiogenesis by generating and releasing, upon activation, factors that promote the growth of new blood vessels. To date, at least 20 angiogenesis-regulating factors have been identified in platelets, including both promoters and inhibitors. Platelet-derived angiogenesis regulators promote angiogenesis during wound healing, tumor growth, and in response to ischemia. Within platelets, angiogenesis regulators are primarily stored in alpha-granules, but are also found in the cytosol or derived from membrane lipids. Their release can be inhibited pharmacologically by anti-platelet agents, which consequently suppress platelet-stimulated angiogenesis. Several years ago, our research group discovered that platelets generate the angiogenesis inhibitor angiostatin independent of the activation state of platelets, and that platelet-derived angiostatin serves to limit the angiogenesis-stimulating effects of platelets. In this review, we summarize the current knowledge of platelet-associated angiogenesis regulators, how they impact angiogenesis, and how they are controlled pharmacologically.

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    © 2012 NRC Research Press. This version of this article is open access and can be downloaded and shared. The original author(s) and source must be cited.
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    • Radziwon-Balicka, A., Moncada de la Rosa, C., and Jurasz, P. (2012). Platelet-associated angiogenesis regulating factors: A pharmacological perspective. Canadian Journal of Physiology and Pharmacology, 90(6), 679-688. doi: 10.1139/y2012-036.