Cardiovascular Research Centre (CVRC)
Through the assembly of an expert team, the CVRC aims to lessen the burden of cardiovascular diseases on society through the generation of new knowledge as to the underlying causes of these disorders.
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Angiostatin inhibits endothelial MMP-2 and MMP-14 expression: A hypoxia specific mechanism of actionDownload
Angiostatin is an angiogenesis inhibitor in part generated by and released from platelets. Since platelets upon thrombus formation can give rise to areas of hypoxia, we investigated the effects of angiostatin on endothelial cell migration and apoptosis during hypoxia. Human microvascular...
Platelets, in addition to maintaining hemostasis, also stimulate angiogenesis by generating and releasing, upon activation, factors that promote the growth of new blood vessels. To date, at least 20 angiogenesis-regulating factors have been identified in platelets, including both promoters and...