This week, we need to do work to address a component of our application that requires immediate attention. As a result, you may experience ERA to be intermittently available. We apologize for any inconvenience this may cause, and thank you for your patience as we attend to the care and feeding of ERA!
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- 5Peripheral Blood Smear
- 5Romanowsky Stain
- 4Abnormal Thrombocytes
- 4Platelet Abnormality
- 5Gloria Kwon
- 5Michelle To
- 5Valentin Villatoro (Supervisor)
- 2Jurasz, P.
- 2Moncada de la Rosa, C.
- 2Radziwon-Balicka, A.
- 7Medicine and Dentistry, Faculty of
- 5Medicine and Dentistry, Faculty of/Medical Laboratory Science, Division of
- 2Graduate Studies and Research, Faculty of
- 2Graduate Studies and Research, Faculty of/Theses and Dissertations
- 2Medicine and Dentistry, Faculty of/Cardiovascular Research Centre (CVRC)
- 1Agricultural, Food and Nutritional Science, Department of
Angiostatin inhibits endothelial MMP-2 and MMP-14 expression: A hypoxia specific mechanism of actionDownload
Angiostatin is an angiogenesis inhibitor in part generated by and released from platelets. Since platelets upon thrombus formation can give rise to areas of hypoxia, we investigated the effects of angiostatin on endothelial cell migration and apoptosis during hypoxia. Human microvascular...
Differences in whole blood gene expression associated with infection time-course and extent of fetal mortality in a reproductive model of type 2 porcine reproductive and respiratory syndrome virus (PRRSV) infectionDownload
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant females causes fetal death and increased piglet mortality, but there is substantial variation in the extent of reproductive pathology between individual dams. This study used RNA-sequencing to characterize the whole...
Blood platelets mediate wound healing by preventing bleeding and by supporting growth of new blood vessels. Blood vessel growth is supported in part by growth factors released from platelet α-granules. Both platelet aggregation and α-granule release are mediated by intracellular signaling...
Platelets, in addition to maintaining hemostasis, also stimulate angiogenesis by generating and releasing, upon activation, factors that promote the growth of new blood vessels. To date, at least 20 angiogenesis-regulating factors have been identified in platelets, including both promoters and...
Background: The cancer stem cell (CSC) theory suggests there are small populations of cancer cells that has stem cell-like characteristics, such as self-renewal. These CSCs are thought to be responsible for initiating new tumors following metastasis. Platelets have also been implicated in cancer...