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- 7Peripheral Blood Smear
- 6Platelet Abnormality
- 6Platelet Satellitism
- 5Romanowsky Stain
- 7Villatoro, Valentin (Supervisor)
- 5Kwon, Gloria
- 5To, Michelle
- 2Fraser, Marion
- 2Jurasz, P.
- 2Moncada de la Rosa, C.
- 9Medicine and Dentistry, Faculty of
- 7Medicine and Dentistry, Faculty of/Medical Laboratory Science, Division of
- 3Graduate Studies and Research, Faculty of
- 3Graduate Studies and Research, Faculty of/Theses and Dissertations
- 2Medicine and Dentistry, Faculty of/Cardiovascular Research Centre (CVRC)
- 1Agricultural, Food and Nutritional Science, Department of
Angiostatin inhibits endothelial MMP-2 and MMP-14 expression: A hypoxia specific mechanism of actionDownload
Angiostatin is an angiogenesis inhibitor in part generated by and released from platelets. Since platelets upon thrombus formation can give rise to areas of hypoxia, we investigated the effects of angiostatin on endothelial cell migration and apoptosis during hypoxia. Human microvascular...
Differences in whole blood gene expression associated with infection time-course and extent of fetal mortality in a reproductive model of type 2 porcine reproductive and respiratory syndrome virus (PRRSV) infectionDownload
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant females causes fetal death and increased piglet mortality, but there is substantial variation in the extent of reproductive pathology between individual dams. This study used RNA-sequencing to characterize the whole...
Genesis and Characterization of Human eNOS-Based Platelet Subpopulations. Implications for Haemostasis and ThrombosisDownload
Background: Myocardial infarction (MI) and ischemic stroke are responsible for nearly half of all cardiovascular deaths in Canada. Platelets play a critical role in MI and ischemic stroke by forming thrombi that occlude coronary and cerebral arteries. In spite of abundant pharmacological agents...
Blood platelets mediate wound healing by preventing bleeding and by supporting growth of new blood vessels. Blood vessel growth is supported in part by growth factors released from platelet α-granules. Both platelet aggregation and α-granule release are mediated by intracellular signaling...