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Differential responses in placenta and fetal thymus at 12 days post infection elucidate mechanisms of viral level and fetal compromise following PRRSV2 infectionDownload
Background:A pregnant gilt infected with porcine reproductive and respiratory syndrome virus (PRRSV) can transmit the virus to her fetuses across the maternal-fetal-interface resulting in varying disease outcomes. However,the mechanisms leading to variation in fetal outcome in response to PRRSV...
Birth Weight, Intrauterine Growth Retardation and Fetal Susceptibility to Porcine Reproductive and Respiratory Syndrome VirusDownload
The severity of porcine reproductive and respiratory syndrome was compared in pregnant gilts originating from high and low birth weight litters. One-hundred and eleven pregnant gilts experimentally infected with porcine reproductive and respiratory syndrome virus on gestation day 85 (±1) were...
Pathologic Evaluation of Type 2 PorcineReproductive and Respiratory SyndromeVirus Infection at the Maternal-FetalInterface of Late Gestation Pregnant GiltsDownload
The pathogenesis of fetal death caused by porcine reproductive and respiratory syndromevirus (PRRSV) remains unclear. The objective of this study was to improve our understand-ing of the pathogenesis by assessing potential relationships between specific histopatho-logical lesions and PRRSV RNA...
T cell development is a highly dynamic process driven by interactions between developing hematopoietic progenitor cells and numerous cell types that nurture their development. Ultimately, signals detected by developing progenitors lead to the activation of cellular signaling pathways that...
Rationale: Eosinophils are “end cell” leucocytes, associated with allergy, asthma and helminthiasis. At sites of inflammation, eosinophils may modulate immune response through expression of the extra-hepatic tryptophan-catabolising enzyme, Indoleamine 2, 3-dioxygenase (IDO). Kynurenines, products...
Variation in Fetal Outcome, Viral Load and ORF5 Sequence Mutations in a Large Scale Study of Phenotypic Responses to Late Gestation Exposure to Type 2 Porcine Reproductive and Respiratory Syndrome VirusDownload
In spite of extensive research, the mechanisms of reproductive disease associated with Porcine Reproductive and Respiratory Syndrome virus (PRRSv) are still poorly understood. The objectives of this large scale study were to evaluate associations between viral load and fetal preservation,...