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- 2Elahi, Shokrollah
- 2Field, Catherine J.
- 2Goruk, Susan
- 2Koleva, Petya
- 2Richard, Caroline
- 1Akinwumi, Segun M
- 18Graduate Studies and Research, Faculty of
- 18Graduate Studies and Research, Faculty of/Theses and Dissertations
- 2Agricultural, Food and Nutritional Science, Department of
- 2Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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- 2WISEST Summer Research Program/WISEST Research Posters
- 4Department of Medical Microbiology and Immunology
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Regulation of Anti-tumor Immunity in Colorectal Cancer by Interaction of Exosome Immune Complexes with Fc gamma ReceptorsDownload
Targeted therapy is difficult for colorectal cancer (CRC) due to lack of conserved tumor associated antigens (TAA). Immunotherapies for CRC directed at TAA that can overcome intestinal tolerance need to be developed to improve survival of CRC patients. Exosomes are extracellular vesicles secreted...
Characterization of Binding of LILRA3 and LILRB2 to the Myelin-Associated Inhibitors and Major Histocompatibility Class I MoleculesDownload
The leukocyte immunoglobulin-like receptor family (LILR) is composed of inhibitory and activating receptors that are widely expressed on immune cells and interact with classical and non-classical MHC-I. Recently, several ligands have been identified for the LILRs including the three...
Choline demands during lactation are high; however, detailed knowledge is lacking regarding the optimal dietary intake during this critical period. The present study was designed to determine the effects of varying intakes of choline on maternal immune function during lactation. Primiparous...
The adaptive immune response against intracellular pathogens is largely mediated by CD8+ T lymphocytes. The clonal expansion and expression of cytolytic and immune stimulatory proteins by CD8+ T cells is responsible for their protective immune function. Prior to exhibiting effector activity,...
Creation of an in-vitro¬ Co-culture Model of Microglia and Retinal Pigment Epithelium Cells for Investigating the Innate Immune Mechanisms of the RetinaDownload
Background: The immune mechanisms of the retina in response to gene therapy have been previously understudied due to assumptions of ocular immune privilege. Ocular immune privilege is the concept that there is a tolerance or reduced immune response to antigen exposure in the eye. With the recent...
Allogeneic hematopoietic chimerism induction via bone marrow transplantation (BMT) is thus far the most robust method for inducing donor antigen specific tolerance to allogeneic grafts. However, limited by the toxicity of the reagents used in conditioning the recipients, the demand of a high dose...
Affinity maturation is the process to improve antibody affinity for an antigen during an adaptive immune response; it is mediated by the immunoglobulin mutator enzyme activation-induced cytidine deaminase (AID). This process is crucial to produce high-affinity memory B-cells and plasma cells. In...
Feeding a diet enriched in docosahexaenoic acid to lactating dams improves the tolerance response to egg protein in suckled pupsDownload
The objective of this study was to determine the effect of feeding a maternal diet supplemented with docosahexaenoic acid (DHA) during the suckling period on the development of the immune system and oral tolerance (OT) in offspring. Dams were randomized to consume one of two nutritionally...
Background: Although pediatric heart transplantation is a life-saving and effective therapy for children with cardiac disease, barriers remain due to a lack of available organs as well as transplant failure due to rejection. This dissertation aimed to increase knowledge related to immune risk...