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Platelet-associated angiogenesis regulating factors: a pharmacological perspective Open Access

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Author or creator
Radziwon-Balicka, A.
Moncada de la Rosa, C.
Jurasz, P.
Additional contributors
Subject/Keyword
Vascular endothelial growth factor
Hemostasis
Angiostatin
Angiogenesis regulators
Platelets
Alpha-granules
Angiogenesis
Endothlial cells
Thrombosis
Type of item
Review
Language
English
Place
Time
Description
Platelets, in addition to maintaining hemostasis, also stimulate angiogenesis by generating and releasing, upon activation, factors that promote the growth of new blood vessels. To date, at least 20 angiogenesis-regulating factors have been identified in platelets, including both promoters and inhibitors. Platelet-derived angiogenesis regulators promote angiogenesis during wound healing, tumor growth, and in response to ischemia. Within platelets, angiogenesis regulators are primarily stored in alpha-granules, but are also found in the cytosol or derived from membrane lipids. Their release can be inhibited pharmacologically by anti-platelet agents, which consequently suppress platelet-stimulated angiogenesis. Several years ago, our research group discovered that platelets generate the angiogenesis inhibitor angiostatin independent of the activation state of platelets, and that platelet-derived angiostatin serves to limit the angiogenesis-stimulating effects of platelets. In this review, we summarize the current knowledge of platelet-associated angiogenesis regulators, how they impact angiogenesis, and how they are controlled pharmacologically.
Date created
2012
DOI
doi:10.7939/R3JD4PS21
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Rights
© 2012 NRC Research Press. This version of this article is open access and can be downloaded and shared. The original author(s) and source must be cited.
Citation for previous publication
Radziwon-Balicka, A., Moncada de la Rosa, C., and Jurasz, P. (2012). Platelet-associated angiogenesis regulating factors: A pharmacological perspective. Canadian Journal of Physiology and Pharmacology, 90(6), 679-688. doi: 10.1139/y2012-036.
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