Download the full-sized PDF
Permanent link (DOI): https://doi.org/10.7939/R3JD4PS21
This file is in the following communities:
|Pharmacy and Pharmaceutical Sciences, Faculty of|
|Medicine and Dentistry, Faculty of|
This file is in the following collections:
|Cardiovascular Research Centre (CVRC)|
Platelet-associated angiogenesis regulating factors: a pharmacological perspective Open Access
- Author or creator
Moncada de la Rosa, C.
- Additional contributors
Vascular endothelial growth factor
- Type of item
Platelets, in addition to maintaining hemostasis, also stimulate angiogenesis by generating and releasing, upon activation, factors that promote the growth of new blood vessels. To date, at least 20 angiogenesis-regulating factors have been identified in platelets, including both promoters and inhibitors. Platelet-derived angiogenesis regulators promote angiogenesis during wound healing, tumor growth, and in response to ischemia. Within platelets, angiogenesis regulators are primarily stored in alpha-granules, but are also found in the cytosol or derived from membrane lipids. Their release can be inhibited pharmacologically by anti-platelet agents, which consequently suppress platelet-stimulated angiogenesis. Several years ago, our research group discovered that platelets generate the angiogenesis inhibitor angiostatin independent of the activation state of platelets, and that platelet-derived angiostatin serves to limit the angiogenesis-stimulating effects of platelets. In this review, we summarize the current knowledge of platelet-associated angiogenesis regulators, how they impact angiogenesis, and how they are controlled pharmacologically.
- Date created
- License information
- © 2012 NRC Research Press. This version of this article is open access and can be downloaded and shared. The original author(s) and source must be cited.
- Citation for previous publication
Radziwon-Balicka, A., Moncada de la Rosa, C., and Jurasz, P. (2012). Platelet-associated angiogenesis regulating factors: A pharmacological perspective. Canadian Journal of Physiology and Pharmacology, 90(6), 679-688. doi: 10.1139/y2012-036.
- Link to related item
- Date Uploaded
- Date Modified
- Audit Status
- Audits have not yet been run on this file.
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 270097
Last modified: 2015:10:12 15:03:28-06:00
Filename: Radziwon-Balicka et al. CJPP 2012.pdf
Original checksum: cdf0414ae13d31a7eef8baa9ddd2faec
Well formed: false
Status message: Unexpected error in findFonts java.lang.ClassCastException: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject cannot be cast to edu.harvard.hul.ois.jhove.module.pdf.PdfDictionary offset=2128
Status message: Outlines contain recursive references.
File title: Radziwon et al. CJPP 2012.pdf
Page count: 29