Download the full-sized PDF
Permanent link (DOI): https://doi.org/10.7939/R3S17T613
This file is in the following communities:
|Agricultural, Food and Nutritional Science, Department of|
This file is in the following collections:
|Journal Articles (Agricultural, Food and Nutritional Science)|
Assessment of the mechanisms exerting glucose-lowering effects of dried peas in glucose-intolerant rats Open Access
- Author or creator
Whitlock, Kevin A.
Field, Catherine J.
Bell, Rhonda C.
Ozga, Jocelyn A.
Chan, Catherine B.
- Additional contributors
- Type of item
- Journal Article (Published)
The present study compared the effects of feeding uncooked pea fractions (embryo v. seed coat) on glucose homeostasis in glucose-intolerant rats and examined potential mechanisms influencing glucose homeostasis. Rats were made glucose intolerant by high-fat feeding, after which diets containing both high-fat and pea fractions were fed for 4 weeks. Rats fed diets containing uncooked pea seed coats low (non-coloured seed coat; NSC) or high (coloured seed coat; CSC) in proanthocyanidins but not embryos had improved oral glucose tolerance (P < 0·05). NSC also lowered fasting and glucose-stimulated insulin secretion (P < 0·05), decreased β-cell mass by 50 % (P < 0·05) and lowered levels of malondialdehyde, a marker of oxidative stress. Furthermore, NSC decreased the mucosal thickness of the colon by 25 % (P < 0·05), which might affect fibre fermentation and other gut functions. Small but statistically significant (P < 0·05) effects consistent with enhanced glucose transport or metabolism were observed in the skeletal muscle of rats fed NSC or CSC, for example, increased levels of AMP-dependent kinase or akt. We conclude that pea seed coats are the fraction exerting beneficial effects on glucose tolerance. Most of the changes were small in amplitude, suggesting that additive effects on multiple tissues may be important. NSC content appeared to have the most beneficial effects in improving glucose homeostasis but our ability to detect the effect of flavonoids may have been limited by their low concentration in the diet.
- Date created
- License information
- © The Authors 2012
- Citation for previous publication
Whitlock, K. A., Kozicky, L., Yee, H., Ha, C., Morris, J., Jin, A., Field, C. J., Bell, R. C., Ozga, J., & Chan, C. B. (2012). Assessment of the mechanisms exerting glucose-lowering effects of dried peas in glucose-intolerant rats. British Journal of Nutrition, 108(S1), s91-s102. http://dx.doi.org/10.1017/S0007114512000736
- Link to related item
- Date Uploaded
- Date Modified
- Audit Status
- Audits have not yet been run on this file.
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 531408
Last modified: 2017:09:06 16:04:56-06:00
Original checksum: 8707124967afb49e268f54c9828bd69c
Well formed: true
File title: 409716 91..102
Page count: 12