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Permanent link (DOI): https://doi.org/10.7939/R3S17T613

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Assessment of the mechanisms exerting glucose-lowering effects of dried peas in glucose-intolerant rats Open Access

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Author or creator
Whitlock, Kevin A.
Kozicky, Lisa
Jin, Alena
Yee, Homun
Ha, Christine
Morris, Jill
Field, Catherine J.
Bell, Rhonda C.
Ozga, Jocelyn A.
Chan, Catherine B.
Additional contributors
Subject/Keyword
Glucose Tolerance
Diabetes
Rats
Dried Peas
Glucose Homeostasis
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
The present study compared the effects of feeding uncooked pea fractions (embryo v. seed coat) on glucose homeostasis in glucose-intolerant rats and examined potential mechanisms influencing glucose homeostasis. Rats were made glucose intolerant by high-fat feeding, after which diets containing both high-fat and pea fractions were fed for 4 weeks. Rats fed diets containing uncooked pea seed coats low (non-coloured seed coat; NSC) or high (coloured seed coat; CSC) in proanthocyanidins but not embryos had improved oral glucose tolerance (P < 0·05). NSC also lowered fasting and glucose-stimulated insulin secretion (P < 0·05), decreased β-cell mass by 50 % (P < 0·05) and lowered levels of malondialdehyde, a marker of oxidative stress. Furthermore, NSC decreased the mucosal thickness of the colon by 25 % (P < 0·05), which might affect fibre fermentation and other gut functions. Small but statistically significant (P < 0·05) effects consistent with enhanced glucose transport or metabolism were observed in the skeletal muscle of rats fed NSC or CSC, for example, increased levels of AMP-dependent kinase or akt. We conclude that pea seed coats are the fraction exerting beneficial effects on glucose tolerance. Most of the changes were small in amplitude, suggesting that additive effects on multiple tissues may be important. NSC content appeared to have the most beneficial effects in improving glucose homeostasis but our ability to detect the effect of flavonoids may have been limited by their low concentration in the diet.
Date created
2012
DOI
doi:10.7939/R3S17T613
License information
© The Authors 2012
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Citation for previous publication
Whitlock, K. A., Kozicky, L., Yee, H., Ha, C., Morris, J., Jin, A., Field, C. J., Bell, R. C., Ozga, J., & Chan, C. B. (2012). Assessment of the mechanisms exerting glucose-lowering effects of dried peas in glucose-intolerant rats. British Journal of Nutrition, 108(S1), s91-s102.  http://dx.doi.org/10.1017/S0007114512000736

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