Journal Articles (Chemistry)

2019-01-31

Maju Joe, Todd L. Lowary

Mycobacteria, including the human pathogen Mycobacterium tuberculosis the causative agent of tuberculosis, produce a complex cell wall structure made of carbohydrates and lipids. The major structural element of the mycobacterial cell wall is a glycoconjugate called the mycolic...

2016-01-01

Dong, Shuai, Indukuri, Kiran, Clive, Derrick L. J., Gao, Jin-Ming

Piperazinedione 13, representing the BC ring system of the anti-prostate cancer fungal metabolite MPC1001 was prepared by a route in which a sulfur-stabilized carbanion derived from 22 cyclizes onto the terminal ester of the chain attached to N1. Another model, 14, was synthesized by cyclization...

2019-01-01

Hattori, Hiroyuki, Mitsunga, Tohru, Clive, Derrick L. J.

Two vanilloids, (5E)-8-(4-hydroxy-3-methoxyphenyl)oct-5-en-4-one (1) and 4-[3-hydroxydecyl]-2-methoxyphenol (2), isolated from the dried seeds of Grains of Paradise (Aframomum melegueta), were synthesized; the latter compound was made as the S-enantiomer and the material derived from the seeds...

2019-06-25

Hattori, Hiroyuki, Mitsunaga, Tohru, Clive, Derrick, L.J.

Two vanilloids, (5E)-8-(4-hydroxy-3-methoxyphenyl)oct-5-en-4-one (1) and 4-[3-hydroxydecyl]-2-methoxyphenol (2), isolated from the dried seeds of Grains of Paradise (Aframomum melegueta), were synthesized; the latter compound was made as the S-enantiomer and the material derived from the seeds...

2015-01-01

Shao, Wenjie, Clive, Derrick L. J.

2-Bromo-3-methoxycyclohex-2-en-1-ones are readily alkylated at C-6 with reactive halides, and then treatment with DBU (2 equiv) in PhMe at room temperature results in smooth loss of bromide and aromatization to resorcinol (monomethyl ethers of defined substitution pattern.

2019-01-30

V. Narasimharao Thota, Michael J. Ferguson, Ryan P. Sweeney, Todd L. Lowary

The O-methyl phosphoramidate (MeOPN) motif is a non-stoichiometric modification of capsular polysaccharides (CPS) in ~70% of all Campylobacter jejuni strains. Infections by C. jejuni lead to food-borne illnesses and the CPS they produce are key virulence factors. The MeOPN phosphorus atom in...

2019-01-31

Sicheng Lin, Todd L. Lowary

Chlorella viruses produce N-linked glycoproteins with carbohydrate moieties that differ in structure from all other N- linked glycans. In addition, unlike most viruses, these organisms do not hijack the biosynthetic machinery of the host to make glycocoproteins; instead, they produce their own...

2014-01-01

Zhang, Qiang, Serpe, Michael J.

A novel diblock copolymer composed of bisphosphonate and pyridine oligomers has been prepared by reversible addition–fragmentation transfer (RAFT) polymerization. Ag ion was introduced into the polymer via its coordination with the pyridine groups, followed by a reduction process to obtain Ag...

2019-01-31

Xiaochao Xue, Ruixiang Blake Zheng, Akihiko Koizumi, Ling Han, John S. Klassen, Todd L. Lowary

Mycobacteria, including the human pathogen Mycobacterium tuberculosis, produce a complex cell wall that is critical for their survival. The largest structural component of the cell wall, the mycolylarabinogalactanpeptidoglycan complex, has at its core a galactan domain composed of...

2018-05-24

Hunter, Carmanah D, Guo, Tianlin, Daskhan, Gour, Richards, Michele R, Cairo, Christopher W.

The plasma membrane of cells contains a diverse array of lipids that provide important structural and biological features. Glycolipids are typically a minor component of the cell membrane and consist primarily of glycosphingolipids (GSLs). GSLs in vertebrates contain a multifarious assortment of...