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- 1Golshahi, Laleh
- 1Milad Kiaee Darunkola
- 1Molaghasem Shemirani, Farzin
- 1Ordoubadi, Mani
- 1Redman, Gillian
- 1Roshchenko, Andriy
This thesis presents recent developments in direct numerical simulations of fluid-structure interaction occurring in biological systems, with particular interest in the modeling of particle deposition within the human respiratory system. Two numerical techniques are proposed. The first one is...
Development of Empirical Models to Predict Deposition of Aerosols in the Extrathoracic Airways of ChildrenDownload
The experimental studies described in this thesis were performed with the goal of measuring deposition of aerosols, inhaled either nasally or orally, in the extrathoracic airways of children in different age groups. We pursued in vitro methods and characterized the deposition of aerosols in the...
In this thesis, several fundamental studies were conducted to tackle some of the unanswered questions in the design and engineering of inhalable microparticles produced via spray drying. Different experimental and theoretical methods were applied to understand the mechanisms that control particle...
The inertial filtration properties of neonatal infant nasal airways are the focus of this thesis. Nasal replicas based on computed tomography (CT) scan images of seven infants between the ages of 5 and 79 days were created using three-dimensional printing. Deposition of inertial sized aerosol...
Inhaled Aerosols Targeted via Magnetic Alignment of High Aspect Ratio Particles: An In Vivo and Optimization StudyDownload
An in vivo study with 19 rabbits was completed. Half of the exposed rabbits had a magnetic field placed externally over their right lung. Magnetic resonance images of the lungs were acquired to determine the iron concentrations in the right and left lung of each animal. The right/left ratio...
The current work focuses on three different aspects of the aerosols involved in Metered Dose Inhaler (MDI) sprays. The efficiency of the drug delivery in different ambient conditions, production of monodisperse solid particles to study the heat and mass transfer processes involved, and study of...
The goal of this thesis work was to develop an idealized adult nasal airway geometry capably of mimicking average regional nasal deposition of droplets emitted from pharmaceutical nasal sprays. The first part of this thesis examined regional deposition within the nose for nasal sprays over a...