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Skip to Search Results- 8Gänzle, Michael G.
- 6Curtis, Jonathan M.
- 5Field, Catherine J.
- 4Guan, Leluo
- 4Stothard, Paul
- 4Wu, Jianping
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Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers
Download2014
Ueda, Keitaro, Ito, Kazuhiro, Kimura, Genki, Moses, Audric, Xiong, Yeping, Kizawa, Yasuo, Curtis, Jonathan M., Barnes, Peter J., Mercado, Nicolas
Anti-oxidant capacity is crucial defence against environmental or endogenous oxidative stress. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that plays a key defensive role against oxidative and cytotoxic stress and cellular senescence. However, Nrf2...
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2014-01-01
The usual analysis of genotype × environment interaction (G × E) is based on the linear regression of genotypic performance on environmental changes (e.g., classic stability analysis). This linear model may often lead to lumping together of the non-linear responses to the whole range of...
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Beneficial effects of simulated gastro-intestinal digests of fried egg and its fractions on blood pressure, plasma lipids and oxidative stress in spontaneously hypertensive rats
Download2014
Majumder, Kaustav, Jahandideh, Forough, Morton, Jude S., Davidge, Sandra T., Kaufman, Susan, Chakrabarti, Subhadeep, Panahi, Sareh, Wu, Jianping
Background We have previously characterized several antihypertensive peptides in simulated digests of cooked eggs and showed blood pressure lowering property of fried whole egg digest. However, the long-term effects of this hydrolysate and its fractions on blood pressure are not known. Therefore,...
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Betulinic acid prevents alcohol-induced liver damage by improving the antioxidant system in mice
Download2014-01-01
Yi, Jine, Xia, Wei, Wu, Jianping, Yuan, Liyun, Wu, Jing, Tu, Di, Fang, Jun, Tan, Zhuliang
Betulinic acid (BA), a pentacyclic lupane-type triterpene, has a wide range of bioactivities. The main objective of this work was to evaluate the hepatoprotective activity of BA and the potential mechanism underlying the ability of this compound to prevent liver damage induced by alcohol in vivo....
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Characterization of novel galactosylated chitin-oligosaccharides and chitosan-oligosaccharides
Download2014-12-01
Black, Brenna A., Yan, Yalu, Galle, Sandra, Hu, Ying, Curtis, Jonathan M., Gänzle, Michael G.
This study determined whether chitin-oligosaccharides and chitosan-oligosaccharides (COS) are suitable acceptor carbohydrates for the LacLM-type β-galactosidase of Lactobacillus plantarum. Enzymatic reactions were carried out with lactose as galactosyl-donor and chitinbiose (N,N′-diacetyl...
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2014
Nguyen, Trinh-Don, Ozga, Jocelyn A., Reinecke, Dennis M., Ferraro, Kiva, Ro, Dae-Kyun, Jin, Alena
Background Proanthocyanidins (PAs) accumulate in the seeds, fruits and leaves of various plant species including the seed coats of pea (Pisum sativum), an important food crop. PAs have been implicated in human health, but molecular and biochemical characterization of pea PA biosynthesis has not...
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Characterization of the altered gene expression profile in early porcine embryos generated from parthenogenesis and somatic cell chromatin transfer
Download2014
Dobrinsky, John, Zhou, Chi, Dixon, Walter T., Dyck, Michael K., Stothard, Paul, Foxcroft, George R., Tsoi, Stephen, Verstegen, John
The in vitro production of early porcine embryos is of particular scientific and economic interest. In general, embryos produced from in vitro Assisted Reproductive Technologies (ART) manipulations, such as somatic cell chromatin transfer (CT) and parthenogenetic activation (PA), are less...
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Characterization of α-Galactooligosaccharides formed via Heterologous Expression of α- 2 Galactosidases from Lactobacillus reuteri in Lactococcus lactis
Download2014-01-01
Wang, Yvonne, Black, Brenna A., Curtis, Jonathan M., Gänzle, Michael G.
α-Galacto-oligosaccharides (α-GOS) are produced by transgalactosylation reactions of α-galactosidase (α-Gal) or by conversion of raffinose family oligosaccharides by levansucrase. Similarly to β-GOS, α-GOS have the potential to mimic glycan receptors on eukaryotic cells and act as molecular...
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2014
Mager, Diana R., Chan, Catherine B., Ambler, Kathryn, Salawi, Hebah, Padwal, Rajdeep S., Ball, Geoff D. C.
Background Severe obesity (SO) in pediatrics has become increasing prevalent in recent decades. The objective of our study was to examine differences in demographic, anthropometric, cardiometabolic, and lifestyle variables in children and youth with SO versus their less overweight/obese (OW/OB)...
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Chemically defined diet alters the protective properties of fructo-oligosaccharides and isomalto-oligosaccharides in HLA-B27 transgenic rats
Download2014
Koleva, Petya, Ketabi, Ali, Dieleman, Levinus A., Gänzle, Michael G., Valcheva, Rosica
Non-digestible oligosaccharides (NDO) were shown to reduce inflammation in experimental colitis, but it remains unclear whether microbiota changes mediate their colitis-modulating effects. This study assessed intestinal microbiota and intestinal inflammation after feeding chemically defined...