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Skip to Search Results- 1Abou Zeinab, Rami M
- 1Al Yousef, Habib Saleh M
- 1Alshareef, Abdulraheem
- 1Armstrong, Stephen, R.
- 1Basonbul, Asmaa A
- 1Bhavanam,Sudha
- 3Leng, Roger (Laboratory Medicine and Pathology)
- 2Bamforth, Fiona (Laboratory Medicine and Pathology)
- 2Damaraju, Sambasivarao (Laboratory Medicine and Pathology)
- 2Keelan, Monika (Laboratory Medicine and Pathology)
- 2Rennie, Robert (Laboratory Medicine and Pathology)
- 2Weinfeld, Michael (Oncology)
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Exposure, Placental Transfer, and Neurodevelopmental Effects of Bisphenol A (BPA) and BPA-Alternatives
DownloadSpring 2018
Bisphenol A (BPA) is an endocrine disruptor widely used in plastics and thermal receipt paper, and frequently detectable in human biofluids. Human studies have shown associations between maternal BPA exposure and developmental effects in children. BPA-alternatives, including bisphenol S (BPS) and...
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Genotoxicity and Mutagenicity of Extractable Organics from Oil Sands Process-Affected Water
DownloadFall 2015
Oil sands process-affected water (OSPW) is produced in the surface mining industry during the hot-water extraction of bitumen from oil-sands ore. Its acid extractable organic (AEO) fraction is known to be acutely toxic, but few studies have addressed its genotoxicity or mutagenicity. Here, the in...
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Importance of donor factors and whole blood processing in the storage injury of red blood cells
DownloadFall 2016
Background: The processing and storage of blood components prior to transfusion are key parts of the blood banking industry. Recently, however, it has been suggested that the long term storage of red blood cells for transfusion could have detrimental clinical implications. In this study we...
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Fall 2018
Tuberculosis (TB) is a chronic pulmonary disease caused by Mycobacterium tuberculosis (Mtb). Mtb spreads by aerosol and infects through the airways. Mtb is phagocytosed by macrophages in the lung, and is able to replicate inside these cells. The initial infection of Mtb with macrophage results in...
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Investigation of the role of UBE4B ubiquitin ligase in p53 regulation in response to DNA damage in ATM-proficient and ATM-deficient cells
DownloadFall 2017
The tumour suppressor protein p53 maintains genomic integrity by coordinating the DNA damage response, which includes growth arrest, DNA damage repair, and apoptotic cell death. p53 is mutated in more than 50% of human cancer, which reflects its importance. The complex mechanism that controls the...
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Liposome-based therapy: An alternative approach to treat Helicobacter pylori infection in high prevalence communities such as Aklavik, NWT
DownloadSpring 2016
Helicobacter pylori infects about half of the world population causing chronic gastritis, peptic ulcer or gastric cancer. The Aboriginal people in Aklavik, NWT, Canada are concerned about gastric cancer because of the high prevalence of H. pylori infection (58%) in their community. H. pylori...
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Fall 2015
The study of Ancient DNA (aDNA), DNA recovered from archaeological and historic post mortem material, has complemented the study of anthropology and archaeology. There are several challenges in the retrieval and analysis of DNA from ancient specimens including exogenous contamination with modern...
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Profiling and Identification of Post-Transcriptional Regulatory Molecules for Human Cancer Cachexia
DownloadSpring 2017
Cancer cachexia (CC) is a multifactorial syndrome characterized by severe depletion of skeletal muscle, with or without fat loss. A majority of cancer patients with incurable cancer are affected with cachexia and it remains an unmet medical need. Gene expression changes at the transcriptional...
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Profiling and Identification of Small Non-coding RNAs as Prognostic Markers for Breast Cancer
DownloadFall 2016
Breast cancer (BC) continues to be one of the leading causes of cancer related death among women. Despite continuous progress in screening, diagnosis and treatment of BC, a subset of patients experience recurrence and/or death. Optimal management of BC has remained a challenge due to these...
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Fall 2016
The p53 family of tumor suppressors is an important group of transcription factors preventing the development of cancer by targeting cell-cycle arrest and apoptosis mediator proteins for transcription. The most studied, p53, is frequently inactivated in carcinomas by mutation or genetic...