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- 1Abou Zeinab, Rami M
- 1Al Yousef, Habib Saleh M
- 1Alshareef, Abdulraheem
- 1Armstrong, Stephen, R.
- 1Basonbul, Asmaa A
- 3Leng, Roger (Laboratory Medicine and Pathology)
- 2Bamforth, Fiona (Laboratory Medicine and Pathology)
- 2Damaraju, Sambasivarao (Laboratory Medicine and Pathology)
- 2Keelan, Monika (Laboratory Medicine and Pathology)
- 2Rennie, Robert (Laboratory Medicine and Pathology)
- 2Weinfeld, Michael (Oncology)
Analytical Characterization of Halobenzoquinones as Emerging Disinfection Byproducts in Disinfected WaterDownload
Water disinfection is necessary for killing pathogens, but it causes an unintended chemical risk from the formation of disinfection byproducts (DBPs). Epidemiological studies show a potential association of water disinfection with increased risk of bladder cancer. It is unknown what DBPs are...
There is evidence that the symptoms associated with sickle cell disease can be relieved by using plant extracts containing anthocyanin (AC) agents. It has been established that ACs were able to reverse sickle cell morphology to a biconcave disc shape. However, no specific form of AC has been...
Characterization of Norovirus strains and a seroprevalence study to understand the fluctuation of outbreak activity in Alberta, CanadaDownload
Norovirus (NoV) is recognized as the leading agent causing gastroenteritis among individuals of all ages. Historical data of NoV outbreak surveillance in Alberta, Canada, from the period July 2000 to June 2008 demonstrated a biennial pattern of NoV outbreak activity, in which peaks of high...
Candida albicans is an opportunistic pathogen and major cause of invasive fungal infections. Choice of antifungal therapy is complicated by the underlying associated diseases of patients infected, other drug interactions, and in vitro susceptibility of the isolate. Echinocandins are emerging as a...
Deletion or substitution of conserved amino acid residues at the tip of the domain IV of Tet(O) impairs tetracycline resistanceDownload
Resistance to tetracycline (Tc), an inhibitor of protein synthesis, decreases its effectiveness for the treatment of bacterial infections. Tc resistance (TcR) can be mediated by the ribosomal protection protein, Tet(O), which was first reported in Campylobacter jejuni, a cause of bacterial...
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase receptor that was initially identified as a potent oncogenic driver in anaplastic large-cell lymphoma (ALCL) in the form of NPM-ALK fusion protein. Various forms of oncogenic ALK proteins have been identified, subsequently, in various...
Delineation of Molecular Mechanisms Underlying the Pathobiology of ALK-positive Anaplastic Large-cell LymphomaDownload
ALK-positive anaplastic large-cell lymphoma (ALK+ALCL) is a rare type non-Hodgkin lymphoma of null/T cell original, preferentially occurs in children and young adults. Approximately 85% of ALK+ALCL patients carry the gene translocation t(2;5)(p23;q35), which results in the generation of the...
Mycobacterium tuberculosis (Mtb), one of the deadliest known human pathogens, infects ~ 2 billion people (33% of the world's population) and remains the leading infectious cause of death. According to the World Health Organization's (WHO) report, 225 million new infections will occur and ~79...
Reoviruses have been shown to infect a very broad range of mammalian sources and infections in humans have been associated with gastrointestinal and respiratory illnesses. While the presence of reovirus in several different water matrices and clinical samples has been reported, the clinical...
Developmental Toxicity from Perfluoroalkyl Acid and Mercury Co-Exposure in Experimental and Epidemiological ModelsDownload
Perfluoroalkyl acids (PFAAs) are synthetic contaminants that are widespread in the environment and routinely detected in human blood. Their prevalence raises concerns over their potential adverse implications on human health, especially from exposure during sensitive stages of development (e.g.,...