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Skip to Search Results- 1Alpaugh, Melanie J
- 1Belosevic, M.
- 1Beveridge, Michelle H
- 1Chen, Christopher B
- 1Clandinin, M.T.
- 1Duffy, Terri-Lynn
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Altered ganglioside metabolism in inflammatory bowel disease and the impact of dietary ganglioside intake
DownloadFall 2014
Gangliosides are integral to the structure and function of the plasma membrane. Ganglioside composition of the small intestinal brush border membrane and apical surface of the colon influence numerous cell processes including microbial attachment, cell division, differentiation, and signaling....
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Spring 2015
This research determined if alteration of plasma membrane by exogenous gangliosides inhibits Helicobacter pylori adhesion to human gastric epithelial cells. The objective was to evaluate the composition of gangliosides from bovine whole raw milk, bovine colostrum and powder buttermilk using...
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Dietary lipids containing gangliosides reduce Giardia muris infection in vivo and survival of Giardia lamblia trophozoites in vitro
Download2004
Suh, M., Belosevic, M., Clandinin, M.T.
We examined whether a ganglioside supplemented diet affected the course of Giardia muris infection in mice and survival of Giardia lamblia trophozoites in vitro. Female CD-1 mice were fed 1 of 5 experimental diets : standard lab chow as a control diet; semi-synthetic diets containing 20% (w/w)...
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Spring 2021
Background: Prostate cancer treatments often lead to side effects including sexual and urinary dysfunction as well as fatigue and poor quality of life. As a means of avoiding these side effects, active surveillance has been introduced as a strategy to manage men with low- to moderate-grade...
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Ganglioside Increases Metastatic Potential and Susceptibility of Prostate Cancer to Gene Therapy in vitro
DownloadFall 2009
Prostate cancer (CaP) is the 2nd most common cancer in North American men. Tumour management strategies are appropriate for early stage disease, but advanced disease has a poor prognosis and requires prompt treatment. Therefore, research into delay of tumour progression and efficacious treatment...
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Fall 2013
Inflammatory bowel disease (IBD) involves chronic inflammation of all or part of the digestive tract. IBD primarily includes ulcerative colitis and Crohn disease. Gangliosides are negatively charged glycosphingolipids that consist of a hydrophobic ceramide and a hydrophilic oligosaccharide chain...
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Gangliosides in Plasma and Chylomicrons of Control Participants and Individuals with Diabetes Fed both a High- and Low-Fat Diet
DownloadFall 2014
Aim: To investigate whether the plasma and chylomicron ganglioside profiles of participants with type 2 diabetes differ from those of matched control participants at 0, 2, 4, 6 and 8 hours postprandial when individuals are fed both a high- and low-fat diet for three days each. Background: Type 2...
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Giardiasis in children attending daycare centers in Guatemala and the therapeutic potential of ganglioside
DownloadSpring 2011
Intestinal enteropathy is a prevalent yet neglected aspect of child malnutrition involving chronic exposure to intestinal pathogens such as Giardia intestinalis. Gangliosides have therapeutic potential for the treatment of giardiasis and intestinal enteropathy. The objectives of the thesis were...
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Guiding treatment selection for advanced prostate cancer with biogenic silver nanoparticles
DownloadFall 2018
Prostate cancer (PCa) is the second most common cancer in men worldwide. Men with advanced PCa often face poor prognosis and are at high risk for mortality. To improve prognosis in this high risk population, targeting a reliable biological factor or marker that predicts a patient’s response...
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Impact of conventional fractionated RT to pelvic lymph nodes and dose-escalated hypofractionated RT to prostate gland using IMRT treatment delivery in high-risk prostate cancer
DownloadFall 2009
Prostate cancer is the most common cancer among Canadian men. The standard treatment in high-risk category is radical radiation, with androgen suppression treatment (AST). Significant disease progression is reported despite this approach. Radiation dose escalation has been shown to improve...