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Spring 2023
Chronic wasting disease (CWD), a neurodegenerative prion disease of cervids, is geographically spreading across North America and Northern Europe. Wild cervids are infected by CWD disproportionately by species and sex. The precise mechanisms and animal behaviours that contribute to the patterns...
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Identification of Signaling Pathways Dysregulated during Scrapie Pathogenesis using a Kinomics Approach
DownloadSpring 2017
Prion diseases are a family of chronic lethal neurodegenerative diseases that affect humans and animals. The conversion of the cellular prion protein (PrPC) to abnormal conformations (PrPSc) is accepted to be required for pathogenesis. However, the molecular mechanisms whereby PrP conversion...
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2006
Aiken, J.M., McKenzie, D., Schramm, P.T., Phillips, K.E., Johnson, C.J.
An unidentified environmental reservoir of infectivity contributes to the natural transmission of prion diseases (transmissible spongiform encephalopathies [TSEs]) in sheep, deer, and elk. Prion infectivity may enter soil environments via shedding from diseased animals and decomposition of...
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Fall 2013
Protein folding involves a stochastic search through the configurational energy landscape towards the native structure. Although most proteins have evolved to fold efficiently into a unique native structure, misfolding (the formation of non-native structures) occurs frequently in vivo causing a...
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The use of modern metabolomics and proteomics to address the health challenges facing the Canadian cattle industry
DownloadFall 2013
Naturally cattle only consumed grass, hay and other forage crops but modern cattle industry has started shifting them from a natural grazing diet to a more balanced grain-rich diet. However, feeding dairy cows grain rich diet is associated with a rapid release of large amounts of SCFA that have...