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Skip to Search Results- 1Alrabeeah, Abdollah A. M.
- 1Caldo, Kristian Mark P.
- 1Causton, Norman D.
- 1Chen, Guanqun
- 1Field, Catherine J.
- 1Holic, Roman
- 11Graduate and Postdoctoral Studies (GPS), Faculty of
- 11Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 1Agricultural, Food and Nutritional Science, Department of
- 1Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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2018-03-03
Holic, Roman, Xu, Yang, Caldo, Kristian Mark P., Singer, Stacy D., Field, Catherine J., Weselake, Randall J., Chen, Guanqun
Punicic acid (PuA; 18: 3Δ 9cis,11trans,13cis ) is an unusual 18-carbon fatty acid bearing three conjugated double bonds. It has been shown to exhibit a myriad of beneficial bioactivities including anti-cancer, anti-diabetes, anti-obesity, antioxidant, and anti-inflammatory properties. Pomegranate...
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Spring 2019
Phosphatidylcholine (PC), the most abundant phospholipid in eukaryotic cells, is an important component of cellular membranes and lipoprotein particles. The enzyme CTP: phosphocholine cytidylyltransferase (CT) regulates de novo PC synthesis in response to changes in membrane lipid composition in...
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Deciphering the mechanism of cytotoxicity and cancer-selective activity of the delocalized lipophilic cation D112
DownloadFall 2016
Chemotherapeutic drugs that are used in anti-cancer treatments often cause death of both cancerous and noncancerous cells. This non-selective toxicity is the root cause of untoward side effects that limits the effectiveness of therapy. To improve the therapeutic options for cancer patients, there...
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Establishing the anti-cancer effects of unsaturated fatty acids and a novel oil on human breast cancer cells
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N-3 and n-6 fatty acids and conjugated linoleic (CLA) acid have been known to inhibit breast cancer cell growth, however, effects on normal cells and of single and mixtures of n-3 and n-6 pathway intermediates have not been thoroughly investigated. The objective of this thesis was to determine...
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Spring 2014
Mandatory folate fortification polices in North America have resulted in high levels of circulating folate in the population. At the same time, a trend toward increased energy intake and reduced energy expenditure has lead to an increased prevalence of obesity, characterized by an accumulation of...
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Fluorogenic and fluorescent bioorthogonal labelling strategies for examining glycoproteins and phospholipids
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Traditional genetically-encoded imaging strategies are problematic for use in analysing cell surface interactions due to the heterogeneous nature of the cell surface, and the high level of post-translational modifications. Small molecule fluorophores can provide dynamic information on cell...
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Spring 2013
Egg yolk contains approximately 10% (w/w) phospholipids (PL), of which about 70% is phosphatidylcholine (PC). Conventional methods of PL extraction from egg yolk involve using hazardous organic solvents. Supercritical carbon dioxide (SC-CO2), as a "green" solvent, had been applied for the...