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Developing a new drug is a complex, highly structured, and expensive task. The further a potential drug progresses in the development process, the more costly its failure becomes. Virtual screening (VS) is the initial stage of a drug discovery process. Its job is to screen large compound...
Molecular Mechanisms Underlying the Regulation of Protein Phosphatase-1c by the Apoptotic Stimulating Proteins of p53Download
Protein phosphatase-1c (PP-1c) is a ubiquitous serine/threonine protein phosphatase regulated in part by association with a large number of different regulatory subunits. Apoptotic Stimulating Proteins of p53 (ASPPs) are a family of proteins that regulate the apoptotic function of the tumour...
Plakoglobin (γ-catenin) is a member of the Armadillo family of proteins and a homolog of β-catenin with similar dual adhesive and signaling functions. The adhesive function of these proteins is mediated by their interactions with cadherins and their signaling function by association with various...
The protein p53 is a key regulator of cellular response to a wide variety of stresses. In cancerous cells inhibitory regulators of the p53 protein such as MDM2 and MDMX are often overexpressed. In silico techniques could be used to inform the selection of interactions to target with novel drug...
The Regulation of p53 by E3 ligases MDM2 and CHIP in Breast Cancer: Analysis of the Role of Hsp70 and Hsp90Download
Tumor suppressor p53 is commonly mutated in breast cancer. Mutant p53 protein is highly stable and oncogenic. This study aims to understand the underlying mechanism of the regulation and stabilization of mutant p53 protein particularly folded mutant p53 R280K. The data showed a possible...