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Skip to Search Results- 12Macrophages
- 6Endocytosis
- 6Phagocytosis
- 3Comparative immunology
- 3Dectin-1
- 3Immunoregulatory receptors
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Fall 2012
Teleosts rely on innate immunity to protect themselves from pathogens. Colony stimulating factor-1 (CSF-1) and its cognate receptor CSF-1R control survival, proliferation, differentiation and function of macrophages. Recently, a novel soluble form of CSF-1R (sCSF-1R) was identified in goldfish....
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Fall 2014
Fungal pathogens are recognized by Dectin-1, a pattern recognition receptor expressed on mammalian innate immune cells. Dectin-1 detects β-glucans, which are polymers of glucose that are a main component of the fungal cell wall. While purified, soluble β-glucans have been used in the clinic as...
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Development of imaging-based techniques to examine signalling properties of channel catfish (Ictalurus punctatus) leukocyte immune-type receptors (IpLITRs)
DownloadSpring 2017
Cells of the innate immune system have the ability to rapidly detect and eliminate pathogens using surface-expressed immunoregulatory receptors that translate extracellular binding into effector functions such as degranulation, cytokine secretion, cell-mediated cytotoxicity, and phagocytosis....
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Effects of macrophages and noggin suppression on the BMP-2-induced osteogenesis of human bone marrow mesenchymal stem cells
DownloadSpring 2011
The osteogenic effects of bone morphogenetic protein-2 (BMP-2) on human mesenchymal stem cells (MSCs) are less profound than expected as compared with rodent cells, and supraphysiological dose of BMP-2 is required to achieve desired clinical outcome. The mechanism for this phenomenon is unclear....
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Spring 2022
The ever-growing market share of electrical transportation and energy storage stations has led to a demand surge for lithium-ion batteries (LIBs). Despite their popularity in global energy storage market, an efficient, sustainable and green method that can recycle spent LIBs is also in active...
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Fall 2013
In response to pathogens, immune cells induce protective effector functions, such as degranulation, phagocytosis and cytokine secretion, which are initiated by stimulatory or inhibitory immunoregulatory receptors expressed on leukocytes. Using a fish immunological model system, the focus of my...
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Examination of channel catfish (Ictalurus punctatus) leukocyte immune-type receptor-mediated crosstalk regulation of phagocytosis
DownloadFall 2020
Across vertebrates, innate immune cells are capable of initiating a range of potent effector responses that are designed to destroy or contain foreign microbial invaders. The execution and regulation of various innate cellular responses is mediated by a dedicated repertoire of cell...
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Examination of the Regulation of Phosphorylation Events in Macrophage Adhesion and Response to Zymosan
DownloadFall 2012
Macrophages play a central role in innate immunity, most notably in tissue repair, phagocytosis of dead or infected cells, secretion of chemokine and cytokines at sites of infection, as well as the activation of other immune cells. These roles are highly dependent on their capacity to migrate...
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Fall 2013
West Nile virus (WNV) is a neurotropic, blood-borne flavivirus that can cause serious neurological disease in humans and animals. While significant progress has been made in identifying virus-encoded pathogenic determinants, very little is known regarding how these viral proteins interact with...