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Skip to Search Results- 2Al-Hallak, MHD Kamal
- 1Acton, Leah T
- 1Anwar-Mohamed, Anwar
- 1Azarmi, Shirzad
- 1Badr, Dina EFA
- 1Chen, Chao
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Analysis of goldfish innate immunity following exposure to oil sands process affected water
DownloadFall 2013
The acute and sub chronic effects of oil sands process affected water (OSPW) and its toxic component, naphthenic acids (NAs) were examined. I exposed goldfish for one (acute), or 12 (sub chronic) weeks and examined immune gene expression, macrophage function, the ability of exposed fish to...
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Analysis of the acute phase response in goldfish (Carassius auratus L.) infected with Trypanosoma carassii
DownloadSpring 2016
The innate immune response is a fundamental defense mechanism in bony fishes and a crucial component of innate immunity is the acute phase response (APR). The APR is a systemic and/or local response to any injury, infection, or trauma and is characterized by a change in the blood composition of...
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Fall 2012
Teleosts rely on innate immunity to protect themselves from pathogens. Colony stimulating factor-1 (CSF-1) and its cognate receptor CSF-1R control survival, proliferation, differentiation and function of macrophages. Recently, a novel soluble form of CSF-1R (sCSF-1R) was identified in goldfish....
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Fall 2014
Fungal pathogens are recognized by Dectin-1, a pattern recognition receptor expressed on mammalian innate immune cells. Dectin-1 detects β-glucans, which are polymers of glucose that are a main component of the fungal cell wall. While purified, soluble β-glucans have been used in the clinic as...
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Characterizing the Role of IL-1β in Macrophage Clearance of Citrobacter rodentium Infection
DownloadFall 2018
Inflammatory Bowel Diseases (IBD) are a group of conditions characterized by chronic inflammation and a dysregulated immune response of the gastrointestinal tract. The etiology is unknown; however, research has indicated a complex relationship between environmental stimuli, genetic...
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Effects of macrophages and noggin suppression on the BMP-2-induced osteogenesis of human bone marrow mesenchymal stem cells
DownloadSpring 2011
The osteogenic effects of bone morphogenetic protein-2 (BMP-2) on human mesenchymal stem cells (MSCs) are less profound than expected as compared with rodent cells, and supraphysiological dose of BMP-2 is required to achieve desired clinical outcome. The mechanism for this phenomenon is unclear....
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Examination of the Regulation of Phosphorylation Events in Macrophage Adhesion and Response to Zymosan
DownloadFall 2012
Macrophages play a central role in innate immunity, most notably in tissue repair, phagocytosis of dead or infected cells, secretion of chemokine and cytokines at sites of infection, as well as the activation of other immune cells. These roles are highly dependent on their capacity to migrate...
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Fall 2013
West Nile virus (WNV) is a neurotropic, blood-borne flavivirus that can cause serious neurological disease in humans and animals. While significant progress has been made in identifying virus-encoded pathogenic determinants, very little is known regarding how these viral proteins interact with...