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Skip to Search Results- 8Keeling, Christopher I.
- 3Bohlmann, Joerg
- 3Bohlmann, Jörg
- 3Bonnett, Tiffany R.
- 3Pitt, Caitlin
- 3Robert, Jeanne A.
- 11Graduate and Postdoctoral Studies (GPS), Faculty of
- 11Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 10The NSERC TRIA Network (TRIA-Net)
- 10The NSERC TRIA Network (TRIA-Net)/Journal Articles (TRIA-Net)
- 5Biological Sciences, Department of
- 5Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 3El-Kadi, Ayman (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Ayman, El-Kadi (Pharmacy and Pharmaceutical Sciences)
- 1Bressler, David (Agricultural, Food and Nutritional Science)
- 1Brocks, Dion (Pharmacy and Pharmaceutical Sciences)
- 1El-Kadi, Ayman (Faculty of pharmacy and pharmaceutical sciences)
- 1El-Kadi, Ayman (Pharmacy and Pharmaceutical Sciences)
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Spring 2010
The western toad (Anaxyrus boreas, formerly Bufo boreas) is one of many amphibian species considered to be at risk of extinction (COSEWIC status is Special Concern). I examined habitat use patterns of the western toad using several methods to gain a better understanding of its habitat...
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IL-6 indirectly modulates the induction of glyceroneogenic enzmes in adipose tissue during exercise
Download2012
Wan, Zhongxiao, Beaudoin, Marie-Soleil, Castellani, Laura, Wright, David C., Ritchie, Ian, Chan, Catherine B.
Background Glyceroneogenesis is an important step in the control of fatty acid re-esterification with PEPCK and PDK4 being identified as key enzymes in this process. We have previously shown that glyceroneogenic enzymes such as PDK4 are rapidly induced in white adipose tissue during exercise....
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Fall 2012
Ischemic heart disease remains a major cause of illness, disability and death worldwide, as such there remains a need for novel pharmacological agents that protect against myocardial ischemia reperfusion (I/R) injury. Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP) epoxygenase...
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MODULATING CYTOCHROME P450-MEDIATED ARACHIDONIC ACID METABOLISM AS A POTENTIAL NEW TREATMENT MODALITY FOR CARDIAC HYPERTROPHY
DownloadSpring 2017
El-Sherbeni, Ahmed Abd El-Hakeem
Arachidonic acid (AA) metabolism has long been a very appealing target for drug discovery and development efforts. Beside cyclooxygenase and lipoxygenase pathways, AA is also metabolized by the recently recognized cytochrome P450 (P450) pathway, forming several biologically-active...
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MODULATION OF ARYL HYDROCARBON RECEPTOR (AHR)-REGULATED CARCINOGEN ACTIVATING ENZYMES BY ORGANIC ARSENICALS: A POTENTIAL THERAPEUTIC TARGET
DownloadSpring 2017
Arsenic is a worldwide environmental pollutant that is associated with skin and several types of internal cancers, such as liver, lung, kidney, urinary bladder, and prostate cancers. Recent reports revealed that organic arsenic metabolites, such as trimethylarsine oxide (TMAO), dimethylarsinic...
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Seasonal shifts in accumulation of glycerol biosynthetic gene transcripts in mountain pine beetle, Dendroctonus ponderosae Hopkins (Coleoptera: Curculionidae), larvae
Download2017
Fraser, Jordie D., Bonnett, Tiffany R., Keeling, Christopher I., Huber, Dezene P.W.
Winter mortality is a major factor regulating population size of the mountain pine beetle, Dendroctonus ponderosae Hopkins (Coleoptera: Curculionidae). Glycerol is the major cryoprotectant in this freeze intolerant insect. We report findings from a gene expression study on an overwintering...
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Statistical prediction of the vitrifiability and glass stability of multi-component cryoprotective agent solutions.
Download2010
Forbes, J. F., Law, G. K., Weiss, A. D., Scheuerman, A., McGann, L. E., Elliott, J. A., Jomha, N. M.
Long-term biologic storage of articular cartilage has proven elusive due to cellular degradation over time or acute damage during attempts at cryopreservation. Vitrification is one option that may result in successful cryopreservation but difficulty with cryoprotective agent (CPA) toxicity at...
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The cytochrome P450 CYP6DE1 catalyzes the conversion of α-pinene into the mountain pine beetle aggregation pheromone trans-verbenol
Download2019-01-01
Chiu, Christine C., Keeling, Christopher I., Bohlmann, Joerg
The recent outbreak of the mountain pine beetle (Dendroctonus ponderosae; MPB) has afected over 20M hectares of pine forests in western North America. During the colonization of host trees, female MPB release the aggregation pheromone (−)-trans-verbenol. (−)-trans-Verbenol is thought to...
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The Effects of Hydraulic Fracturing Flowback and Produced Water on Exercise Capacity and Metabolic Fuel Selection in Rainbow Trout (Oncorhynchus mykiss)
DownloadFall 2022
Hydraulic fracturing is an increasingly popular technique for unconventional hydrocarbon extraction in Canada. As its popularity continues to grow, concerns are being raised regarding its waste product, hydraulic fracturing flowback and produced water (FPW), and its effects on the environment....
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The role of cytochrome P450 and the protective effect of EETs against isoproterenol-induced cellular hypertrophy in rat H9c2 cell line
DownloadSpring 2013
Cytochrome P450 (CYP) enzymes have been identified in the heart and their levels have been reported to be altered during cardiac hypertrophy and heart failure. Furthermore, CYP enzymes have been shown to metabolize arachidonic acid to cardioprotective epoxyeicosatrienoic acids (EETs) and...