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Skip to Search Results- 1Ahrari, Malema
- 1Froentjes, Liesbeth
- 1Goplen, Craig M
- 1Greenberg, Anastasia
- 1Kantor, Chase M
- 1Kerridge, Teresa A.
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Antagonistic modulation of spontaneous neural network activities in isolated newborn rat brainstem preparations by opioids and methylxanthines
DownloadFall 2012
Apnea of prematurity is a common problem among the infants born before term pregnancy. Administration of respiratory stimulating drugs methylxanthines is the most frequent therapy, often in combination with the use of intubation. Opioids are used to reduce the pain associated with intubation,...
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Calcium Imaging and Field Potential Analysis of Autocrine Neuromodulation in the Locus Coeruleus of Newborn Rat Brain Slices
DownloadFall 2022
The locus coeruleus (LC) is a small brainstem nucleus that controls diverse behaviours and brain functions via release of noradrenaline (NA) in the neonatal time period. There is increasing evidence of complexity in this neuron-astrocyte ‘neural’ network that remains mostly unexplored in...
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Efficacy and side-effect profiles of lactulose, docusate sodium, and sennosides compared to PEG in opioid-induced constipation: A systematic review
DownloadSpring 2012
Opioid-induced constipation (OIC) is an unpleasant and ubiquitous side effect of opioid treatment. Ineffective treatment of OIC can result in decreased adherence to opioid therapy, decreased quality of life, and increased morbidity and mortality. The constipating effects of opioids result from...
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Fall 2016
Oscillations are a fundamental principle of neural operation, organized into a hierarchy of frequency bands with the dominant rhythm alternating within and across behavioral states. During states of sleep and anesthesia, brain activity in forebrain regions displays two major distinct activity...
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Enteral diet and necrotizing enterocolitis in neonates: a scoping review and parent outcome prioritization project
DownloadFall 2017
Necrotizing enterocolitis (NEC) is a potentially life-threatening inflammatory disease of the gut affecting newborns, especially preterm infants. This complex disease is affected by numerous risk factors including genetics, intestinal microbiota, immune system responses, cardiac or respiratory...
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Magnetic Resonance Imaging of the Brain in Prenatal Alcohol Exposure and Advances in Measuring Cortical Microstructure
DownloadFall 2020
Fetal alcohol spectrum disorder (FASD) encompasses a large spectrum of physical, cognitive and behavioral deficits resulting from prenatal alcohol exposure. Studies using magnetic resonance imaging (MRI) have shown structural and functional brain alterations in children and adolescents with...
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Mechanisms of Neonatal Intestinal Failure-Associated Liver Disease: Exploring the Gut-Liver Axis
DownloadSpring 2018
Neonates with intestinal failure (IF), who must rely on parenteral nutrition (PN) for growth and maintenance of health, are at risk for intestinal failure-associated liver disease (IFALD). In neonates, short bowel syndrome (SBS) as a result of intestinal resection is the most common cause of IF....
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Modulation of Spontaneous Neural Network Bursting in Newborn Rat Brain Slices by Extracellular Calcium, Methylxanthines, and Opioids
DownloadFall 2012
Spontaneous neuronal bursting appears to be pivotal for brain maturation. This thesis studied such synchronized neural network oscillations in immature newborn rat hippocampus, cortex, and locus coeruleus. For this, horizontal brain slices were generated for (simultaneous) suction electrode...