Efficacy and side-effect profiles of lactulose, docusate sodium, and sennosides compared to PEG in opioid-induced constipation: A systematic review

  • Author / Creator
    Kerridge, Teresa A.
  • Opioid-induced constipation (OIC) is an unpleasant and ubiquitous side effect of opioid treatment. Ineffective treatment of OIC can result in decreased adherence to opioid therapy, decreased quality of life, and increased morbidity and mortality. The constipating effects of opioids result from their inhibitory effects on μ, κ, and δ receptors in the gastrointestinal tract causing hard and dry stools, prolonged transit time, decreased gastric secretions, and ineffective colonic emptying. Current treatment of OIC occurs by trial and error; little evidence exists to guide practice. Docusate sodium, sennosides, and lactulose are common drugs used in constipation prevention and management in OIC. This systematic review investigates whether PEG is superior to doscusate sodium, sennosides, and/or lactulose in the treatment of OIC. Despite extensive search strategies, no studies met our inclusion criteria. Consequently, insufficient evidence exists to address this clinical question. Further research is required and high-powered, well-designed clinical trials are economically feasible.

  • Subjects / Keywords
  • Graduation date
  • Type of Item
  • Degree
    Master of Nursing
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
  • Institution
    University of Alberta
  • Degree level
  • Department
  • Supervisor / co-supervisor and their department(s)
  • Examining committee members and their departments
    • Hunter, Kathleen (Nursing)
    • Lazarescu, Adriana (Gastroenterology)
    • Cummings, Greta (Nursing)