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Skip to Search Results- 1Hagen, Mariel O
- 1Havixbeck, Jeffrey J
- 1Katzenback, Barbara A
- 1Kovacevic, Nikolina
- 1Lund, Johanna M
- 1McAllister, Mark
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Analysis of goldfish innate immunity following exposure to oil sands process affected water
DownloadFall 2013
The acute and sub chronic effects of oil sands process affected water (OSPW) and its toxic component, naphthenic acids (NAs) were examined. I exposed goldfish for one (acute), or 12 (sub chronic) weeks and examined immune gene expression, macrophage function, the ability of exposed fish to...
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Analysis of the acute phase response in goldfish (Carassius auratus L.) infected with Trypanosoma carassii
DownloadSpring 2016
The innate immune response is a fundamental defense mechanism in bony fishes and a crucial component of innate immunity is the acute phase response (APR). The APR is a systemic and/or local response to any injury, infection, or trauma and is characterized by a change in the blood composition of...
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Fall 2012
Teleosts rely on innate immunity to protect themselves from pathogens. Colony stimulating factor-1 (CSF-1) and its cognate receptor CSF-1R control survival, proliferation, differentiation and function of macrophages. Recently, a novel soluble form of CSF-1R (sCSF-1R) was identified in goldfish....
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Pathophysiology in fish trypanosomiasis: The interaction between Trypanosoma carassii and goldfish erythropoietic system during the course of infection
DownloadFall 2019
Trypanosoma carassii is a hemoflagellate parasite that infects a variety of cyprinid fish. The primary pathophysiology of T. carassii infections in fish is the onset of a prolonged anemia, characterized by significant decreases in the number of circulating red blood cells during peak parasitemia....
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Spring 2012
Development of progenitor cells into myeloid cells (i.e. macrophages and neutrophils) is critical to the survival of metazoans for maintenance of homeostasis and defense against pathogens. While much is known about myeloid cell development in mammals, less is known about this process in fish. The...
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Studies on the mechanisms of immune evasion in Trypanosoma carassii infections of the goldfish (Carassius auratus)
DownloadSpring 2012
Parasites possess variety of mechanisms to modulate or evade host defence systems to maintain chronic infection and ensure their transmission. The protozoan parasite Trypanosoma carassii is infective to a number of freshwater fish species and can cause significant mortality in aquaculture. T....
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Fall 2017
The inflammatory response is a complex biological process initiated following the recognition of noxious stimuli. It is composed of an elaborate cascade of both pro- and anti-inflammatory mediators, essential for effective defenses against infection, the removal of damaged cells, and the...
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Toxic effects induced in mammalian immune cells after in vitro exposure to oil sands process-affected water and its fractions
DownloadFall 2019
Oil sands process-affected water (OSPW) is produced by the surface mining industry in Alberta as a byproduct of the Clark hot water process, the currently used extraction method of crude oil from bitumen/tar sands. Under a provincial zero release policy all produced OSPW must be stored on site....