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Skip to Search Results- 27Alzheimer's disease
- 11Cognitive impairment
- 4Dementia
- 3Amyloid precursor protein
- 3Interventions
- 3Meta-analysis
- 22Graduate and Postdoctoral Studies (GPS), Faculty of
- 22Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 10Nursing, Faculty of
- 8Nursing, Faculty of/Chronicity
- 2Rehabilitation Medicine, Faculty of
- 2Rehabilitation Medicine, Faculty of/Speech Pathology and Audiology
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2002
This is the protocol for a review and there is no abstract. The objectives are as follows: The primary objective is a systematic review of evidence relating to clinical efficacy and safety of melatonin in treatment of manifestations of dementia or cognitive impairment (CI).
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2005
Forbes, D., Morgan, D.G., Jansen, S.L., Duncan, V.
This is the protocol for a review and there is no abstract. The objectives are as follows: The primary objective is a systematic review of evidence relating to the clinical efficacy and safety of melatonin in the treatment of manifestations of dementia or cognitive impairment (CI).
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2007
Forbes, D.A., Wood, J., Morgan, D., Taylor, B., Markle-Reid, M., Forbes, S.C.
This is the protocol for a review and there is no abstract. The objectives are as follows: 1.To evaluate the effects of physical activity programs on function (e.g., activities of daily [ADLs], physical function), cognition, mood, behaviour, and mortality in older persons with dementia. 2.To...
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2008
Morgan, D., Wood, J., Culum, I., Markle-Reid, M., Forbes, S.C., Forbes, D.A.
Background. There is some evidence that physical activity delays the onset of dementia in healthy older adults and slows down cognitive decline to prevent the onset of cognitive disability. Studies using animal models suggest that physical activity has the potential to attenuate the...
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Putative ante-mortem indicators of Alzheimer’s dementia: Analysis of fluid biomarker and neuroimaging studies
DownloadSpring 2019
Dementia is a clinical state, characterized by symptoms indicative of deterioration of memoryand cognitive functions that interferes with social or occupational functioning. According to2018 statistics, around 50 million people are living with dementia, and this number will increaseto 131.5...
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Role of Glutamate and GABA in a mouse model expressing mutant human APP in the absence of NPC1 protein
DownloadSpring 2013
Cholesterol plays a critical role in Alzheimer’s disease (AD) pathogenesis, but the underlying mechanisms remain unclear. To address this issue we have generated a line of ANPC transgenic mice that overexpress mutant-human amyloid precursor protein in the absence of cholesterol transporting...
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Roles of the Insulin-like Growth Factor-II/Cation-independent Mannose 6-phosphate Receptor and Cathepsin D in Alzheimer’s Disease Pathology
DownloadSpring 2016
Alzheimer’s disease (AD) is the most common type of senile dementia affecting the elderly. A critical contributing factor to the neurodegeneration and development of AD pathology stems from the processing of amyloid precursor protein (APP), leading to the generation of β-amyloid (Aβ) peptides....