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Skip to Search Results- 4Klassen, John S.
- 4Liu, Lan
- 4Lowary, Todd L.
- 4Wu, Jianping
- 3Chakrabarti, Subhadeep
- 3Majumder, Kaustav
- 22Graduate and Postdoctoral Studies (GPS), Faculty of
- 22Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 12Agricultural, Food and Nutritional Science, Department of
- 12Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 4Chemistry, Department of
- 4Chemistry, Department of/Journal Articles (Chemistry)
- 5Department of Agricultural, Food, and Nutritional Science
- 2Department of Oncology
- 2Department of Pharmacology
- 2Department of Physiology
- 1Department of Agricultural, Food and Nutritional Science
- 1Department of Biochemistry
- 2Proctor, Spencer (AFNS)
- 1Bell, Gordon (Physical Education and Recreation)
- 1Carlos A Velázquez (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Curtis, Jonathan (Agricultural, Food and Nutritional Science)
- 1Curtis, Jonathan (Department of Agricultural, Food and Nutritional Science)
- 1Davidge, Sandra (dept. of Physiology)
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Fall 2016
Lipidomics is a research field that attempts to achieve the comprehensive analysis of the entire lipidome in a biological system. The emergence and rapid expansion of lipidomic studies is driven by the great advances in chromatographic separation and mass spectrometry. For this dissertation, I...
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1999-01-01
Xie, Changping, Albrecht, Elke, Wegner, Jochen J., Brockmann, Gudrun A., Kazala, Christopher, Weselake, Randall J., Ender, Klaus
Leptin is a hormone involved in the regulation of feed intake and energy balance in animals. The expression and secretion of leptin is highly correlated with body fat mass and adipocyte size. The regulation of leptin is integrated into a broad regulatory network including other hormones and...
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Spring 2013
Huntington disease (HD) is a neurodegenerative disorder characterized by motor and cognitive symptoms. In HD patients, the protein huntingtin contains an abnormal expansion of a polyglutamine tract, which leads to the selective dysfunction and death of striatal and cortical neurons. Among other...
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Lipid metabolism, adipocyte depot physiology and utilization of meat animals as experimental models for metabolic research
Download2010-01-01
Dodson, Michael V., Hausman, Gary J., Guan, LeLuo, Du, Min, Rasmussen, Theodore P., Poulos, Sylvia P., Mir, Priya, Bergen, Werner G., Fernyhough, Melinda E., McFarland, Douglas C., Rhoads, Robert P., Soret, Beatrice, Reecy, James M., Velleman, Sandra G., Jiang, Zhihua
Meat animals are unique as experimental models for both lipid metabolism and adipocyte studies because of their direct economic value for animal production. This paper discusses the principles that regulate adipogenesis in major meat animals (beef cattle, dairy cattle, and pigs), the definition...
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Spring 2015
Protein silencing by small interfering RNA (siRNA) is a promising treatment strategy for cancer as over-expression of proteins is largely responsible for cancer cells’ infinite proliferation, evasion of cell death and multi-drug resistance. However, siRNAs require a carrier as their biological...
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Fall 2019
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Abnormal levels of circulating lipids (dyslipidemia) is a well-known risk factor for CVD. Traditionally, fasting lipids, inclusive of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC), have...
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Milk-derived tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) promote adipocyte differentiation and inhibit inflammation in 3T3-F442A cells
Download2015
Chakrabarti, Subhadeep, Wu, Jianping
Milk derived tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) have shown promise as anti-hypertensive agents due to their inhibitory effects on angiotensin converting enzyme (ACE). Due to the key inter-related roles of hypertension, chronic inflammation and insulin resistance in the...
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Molecular targets of antihypertensive peptides: Understanding the mechanisms of action based on the pathophysiology of hypertension
Download2015
Majumder, Kaustav, Wu, Jianping
There is growing interest in using functional foods or nutraceuticals for the prevention and treatment of hypertension or high blood pressure. Although numerous preventive and therapeutic pharmacological interventions are available on the market, unfortunately, many patients still suffer from...
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Non-fasting remnant cholesterol as a predictor for cardiovascular disease risk in Canadians with and without diabetes mellitus in the Alberta’s Tomorrow Project
DownloadFall 2022
Cardiovascular disease (CVD) is a leading cause of death in Canada, and its risk of development is 3 times greater in those with diabetes mellitus (DM). Fasting low-density lipoprotein cholesterol (LDL-C) is the traditional lipid biomarker used in CVD risk assessment. While lowering LDL-C does...
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Notch regulates the growth-promoting nitric oxide cGMP-dependent pathway in epithelial ovarian cancer and ovarian surface epithelium cells
DownloadSpring 2014
El-Sehemy, Ahmed Ali Ahmed Ali
Ovarian cancer is the leading cause of mortality among gynecologic cancers. There are several subtypes of ovarian cancer, amongst which epithelial ovarian cancer (EOC) makes up to 90% of all ovarian cancers. The current treatment for EOC consists of debulking surgery followed by a...