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Skip to Search Results- 3Wu, Jianping
- 2Chakrabarti, Subhadeep
- 2Curtis, Jonathan M.
- 2Davidge, Sandra T.
- 2Kaufman, Susan
- 2Majumder, Kaustav
- 34Graduate and Postdoctoral Studies (GPS), Faculty of
- 34Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 7Agricultural, Food and Nutritional Science, Department of
- 7Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 2Biological Sciences, Department of
- 1Biological Sciences, Department of/Journal Articles (Biological Sciences)
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Fall 2023
Polysialic acid (polySia) is a long homopolymer of sialic acid residues that has profound consequences for the proteins it is attached to. Its expression is restricted in healthy human adults to the nervous, reproductive, and immune systems. It contributes to neuronal development and plasticity...
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A proteome-level analysis of the canola/Sclerotinia sclerotiorum interaction and sclerotial development
DownloadFall 2010
The fungal pathogen Sclerotinia sclerotiorum (Lib.) de Bary is capable of infecting over 400 plant species including canola (Brassica napus L.). The fungus secretes oxalic acid (OA), which plays an important role in infection and disease progression. An analysis of proteome-level changes...
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Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers
Download2014
Ueda, Keitaro, Ito, Kazuhiro, Kimura, Genki, Moses, Audric, Xiong, Yeping, Kizawa, Yasuo, Curtis, Jonathan M., Barnes, Peter J., Mercado, Nicolas
Anti-oxidant capacity is crucial defence against environmental or endogenous oxidative stress. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that plays a key defensive role against oxidative and cytotoxic stress and cellular senescence. However, Nrf2...
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Spring 2016
The simultaneous quantification of all biological molecules, from metabolites to proteins, holds the key to discovering molecular signatures that can diagnose diseases before irreversible damages have occurred in the body. Recent advances in the field of liquid chromatography coupled mass...
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An investigation of aminoglutethimide cytotoxicity and its role in activation of cell death signaling pathways
DownloadFall 2013
Aminoglutethimide (AG), a drug used for the treatment of breast and ovarian cancers, is known to cause toxicities such as agranulocytosis. To investigate its toxicity mechanisms, we have used quantitative proteomic analysis to gain insight into the proteome of Human Leukemia 60 (HL-60) treated...
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Fall 2016
Antemortem identification of Creutzfeldt-Jakob disease (CJD) patients is initially based upon clinical presentation of the disease. Symptoms are assessed in combination with results from cerebrospinal fluid (CSF) analysis, electroencephalography (EEG), magnetic resonance imaging (MRI), and...
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Antioxidants in Chicken Egg Yolk: Effects of Cooking, Storage and Gastrointestinal Digestion
DownloadSpring 2015
Nimalaratne, Liyana Arachchilage Chamila K.
Eggs are one of the most nutritious and economically affordable foods. They contain high quality proteins and lipids and serve as an important source of vitamins and minerals. Despite the nutritional importance, the egg industry is vulnerable to the consumers’ perception about egg cholesterol and...
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Beneficial effects of simulated gastro-intestinal digests of fried egg and its fractions on blood pressure, plasma lipids and oxidative stress in spontaneously hypertensive rats
Download2014
Majumder, Kaustav, Jahandideh, Forough, Morton, Jude S., Davidge, Sandra T., Kaufman, Susan, Chakrabarti, Subhadeep, Panahi, Sareh, Wu, Jianping
Background We have previously characterized several antihypertensive peptides in simulated digests of cooked eggs and showed blood pressure lowering property of fried whole egg digest. However, the long-term effects of this hydrolysate and its fractions on blood pressure are not known. Therefore,...