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- 1Drug-induced agranulocytosis
- 1Free radicals
- 1HL-60 cells
- 1Idiosyncratic drug reactions
An investigation of aminoglutethimide cytotoxicity and its role in activation of cell death signaling pathwaysDownload
Aminoglutethimide (AG), a drug used for the treatment of breast and ovarian cancers, is known to cause toxicities such as agranulocytosis. To investigate its toxicity mechanisms, we have used quantitative proteomic analysis to gain insight into the proteome of Human Leukemia 60 (HL-60) treated...