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Skip to Search Results- 17Harding, John C. S.
- 13Plastow, Graham S.
- 11Lunney, Joan K.
- 9Dekkers, Jack C. M.
- 7Ladinig, Andrea
- 6Bao, Hua
- 21PigGen Canada
- 21PigGen Canada/Journal Articles
- 3Roy Berg Kinsella Research Ranch
- 3Roy Berg Kinsella Research Ranch/Journal Articles (Kinsella Ranch)
- 2Agricultural, Food and Nutritional Science, Department of
- 2Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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Differential responses in placenta and fetal thymus at 12 days post infection elucidate mechanisms of viral level and fetal compromise following PRRSV2 infection
Download2020-01-01
Van Goor, Angelica, Pasternak, Alex, Walker, Kristen, Hong, Linjun, Malgarin, Carolina, MacPhee, Daniel J., Harding, John C. S., Lunney, Joan K.
Background:A pregnant gilt infected with porcine reproductive and respiratory syndrome virus (PRRSV) can transmit the virus to her fetuses across the maternal-fetal-interface resulting in varying disease outcomes. However,the mechanisms leading to variation in fetal outcome in response to PRRSV...
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Putting the microbiota to work: Epigenetic effects of early life antibiotic treatment are associated with immune-related pathways and reduced epithelial necrosis following Salmonella Typhimurium challenge in vitro
Download2020-04-01
Costa, Matheus O., Fouhse, Janelle, Silva, Ana Paula P., Wiling, Benjamin, Harding, John C. S.
Salmonella enterica serovar Typhimurium is an animal welfare and public health concern due to its ability to parasite livestock and potentially contaminate pork products. To reduce Salmonella shedding and the risk of pork contamination, antibiotic therapy is used and can contribute to...
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Type 2 porcine reproductive and respiratory syndrome virus infection increases apoptosis at the maternal-fetal interface in late gestation pregnant gilts
Download2017-03-01
Novakovic, Predrag, Harding, John C. S., Al-Dissi, Ahmad N., Detmer, Susan E.
The pathogenesis of fetal death associated with porcine reproductive and respiratory syndrome (PRRS) is hypothesized to be a consequence of PRRS virus-induced apoptosis at the maternal-fetal interface (MFI). The objectives of this study were to evaluate distribution and degree of apoptosis in the...
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Relationships of CD163 and CD169 positive cell numbers in the endometrium and fetal placenta with type 2 PRRSV RNA concentration in fetal thymus
Download2016-08-05
Novakovic, Predrag, Harding, John C. S., Ladning, Andrea, Al-Dissi, Ahmad N., MacPhee, Daniel J., Detmer, Susan E.
Several routes of porcine reproductive and respiratory virus PRRSV transmission across the porcine diffuse epitheliochorial placentation have been proposed, but none have been proven. The objectives of this study were to investigate associations between numbers of CD163 and CD169 positive...
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A genome-wide association study of fetal response to type 2 porcine reproductive and respiratory syndrome virus challenge
Download2016-02-05
Plastow, Graham, Ladinig, Andrea, Harding, John, Wang, Zhiquan, Wilkinson, James, Yang, Tianfu
Control of porcine reproductive and respiratory syndrome (PRRS) is economically important for the swine industry worldwide. As current PRRS vaccines do not completely protect against heterologous challenge, alternative means of control, including enhanced genetic resilience, are needed. For...
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Bioinformatic analyses in early host response to Porcine Reproductive and Respiratory Syndrome virus PRRSV reveals pathway differences between pigs with alternate genotypes for a major host response QTL
Download2016-03-08
Bao, Hua, Schroyen, Martine, Rowland, Robert R.R., Guan, Le L., Stothard, Paul, Reecy, James M., Fritz-Waters, Eric, Koltes, James E., Kommadath, Arun, Plastow, Graham S., Eisley, Christopher, Tuggle, Christopher K. , Dekkers, Jack C.M., Lunney, Joan K., Choi, Igseo
Background A region on Sus scrofa chromosome 4 (SSC4) surrounding single nucleotide polymorphism (SNP) marker WUR10000125 (WUR) has been reported to be strongly associated with both weight gain and serum viremia in pigs after infection with PRRS virus (PRRSV). A proposed causal mutation in the...
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Comparison of host genetic factors influencing pig response to infection with two North American isolates of porcine reproductive and respiratory syndrome virus
Download2016-01-01
Hess, Andrew S., Islam, Zeenath, Hess, Melanie K., Rowland, Raymond R. R., Lunney, Joan K., Doeschl-Wilson, Andrea, Plastow, Graham S., Dekkers, Jack C. M.
Background:Porcine reproductive and respiratory syndrome (PRRS) is one of the most important swine diseases in the world and genetic selection of pigs for increased resistance to PRRS is an attractive method to improve the health status of the swine herd. This study compared phenotypic and...
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Differences in Whole Blood Gene ExpressionAssociated with Infection Time-Course andExtent of Fetal Mortality in a ReproductiveModel of Type 2 Porcine Reproductive andRespiratory Syndrome Virus (PRRSV)Infection
Download2016-04-19
Wilkinson, Jamie M., Ladinig, Andrea, Bao, Hua, Kommadath, Arun, Stothard, Paul, Lunney, Joan K., Harding, John C. S., Plastow, Graham S.
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnantfemales causes fetal death and increased piglet mortality, but there is substantial variationin the extent of reproductive pathology between individual dams. This study used RNA-sequencing to characterize the whole...
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Differences in whole blood gene expression associated with infection time-course and extent of fetal mortality in a reproductive model of type 2 porcine reproductive and respiratory syndrome virus (PRRSV) infection
Download2016
Ladinig, Andrea, Stothard, Paul, Wilkinson, Jamie M., Kommadath, Arun, Plastow, Graham S., Harding, John C. S., Bao, Hua, Lunney, Joan K.
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant females causes fetal death and increased piglet mortality, but there is substantial variation in the extent of reproductive pathology between individual dams. This study used RNA-sequencing to characterize the whole...
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Exploring Phenotypes for Disease Resilience in Pigs Using Complete Blood Count Data From a Natural Disease Challenge Model
Download2020-01-01
Bai, Xuechun, Putz, Austin M., Wang, Zhiquan, Fortin, Frederic, Harding, John C. S., Dyck, Michael K., Dekkers, Jack C. M., Field, Catherine J., Plastow, Graham S., PigGen Canada
Disease resilience is a valuable trait to help manage infectious diseases in livestock. It is anticipated that improved disease resilience will sustainably increase production efficiency, as resilient animals maintain their performance in the face of infection. The objective of this study was to...