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Skip to Search Results- 37Stothard, Paul
- 9Bao, Hua
- 9Plastow, Graham S.
- 8Liang, Guanxiang
- 8Moore, Stephen S.
- 8Wishart, David S.
- 35Agricultural, Food and Nutritional Science, Department of
- 35Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 5Roy Berg Kinsella Research Ranch
- 5Roy Berg Kinsella Research Ranch/Journal Articles (Kinsella Ranch)
- 5PigGen Canada
- 5PigGen Canada/Journal Articles
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Genome-wide analysis of thetranscriptional response to porcinereproductive and respiratory syndromevirus infection at the maternal/fetalinterface and in the fetus
Download2016-01-01
Wilkinson, Jamie M., Bao, Hua, Ladinig, Andrea, Hong, Linjun, Stothard, Paul, Lunney, Joan K., Plastow, Graham S., Harding, John C. S.
Background:Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant pigs can result incongenital infection and ultimately fetal death. Little is known about immune responses to infection at thematernal-fetal interface and in the fetus itself, or the molecular events...
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Genome-wide association and genomic prediction of breeding values for fatty acid composition in subcutaneous adipose and longissimus lumborum muscle of beef cattle
Download2015
Ekine-Dzivenu, Chinyere, Basarab, John A., Li, Changxi, Chen, Liuhong, Vinsky, Michael D., Aalhus, Jennifer L., Fitzsimmons, Carolyn J., Stothard, Paul, Dugan, Mike E. R.
Background Identification of genetic variants that are associated with fatty acid composition in beef will enhance our understanding of host genetic influence on the trait and also allow for more effective improvement of beef fatty acid profiles through genomic selection and marker-assisted diet...
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Genome-wide association for milk production and female fertility traits in Canadian dairy Holstein cattle
Download2016
Nayeri, Shadi, Stothard, Paul, Moore, Stephen S., Abo-Ismail, Mohammed K., May, Natalie, Schenkel, Flavio, Sargolzaei, Mehdi, Miller, Stephen P.
Background Genome-wide association studies (GWAS) are a powerful tool for detecting genomic regions explaining variation in phenotype. The objectives of the present study were to identify or refine the positions of genomic regions affecting milk production, milk components and fertility traits in...
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Genome-wide whole blood microRNAome and transcriptome analyses revealed miRNA-mRNA regulated host response to foodborne pathogen Salmonella infection in swine
Download2015-07-31
Arantes, Adriano S., Tuggle, Christopher K., Guan, Le L., Bearson, Shawn M.D., Sun, Xu, Plastow, Graham S., Kommadath, Arun, Bao, Hua, Stothard, Paul, Liang, Guanxiang
To understand the role of miRNAs in regulating genes involved in host response to bacterial infection and shedding of foodborne pathogens, a systematic profiling of miRNAs and mRNAs from the whole blood of pigs upon Salmonella challenge was performed. A total of 62 miRNAs were differentially...
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2010
Dennis, Jonathan J., Stothard, Paul, Lynch, Karlene H.
Background The Burkholderia cepacia complex (BCC) is comprised of at least seventeen Gram-negative species that cause infections in cystic fibrosis patients. Because BCC bacteria are broadly antibiotic resistant, phage therapy is currently being investigated as a possible alternative treatment...
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Harnessing cross-species alignment to discover SNPs and generate a draft genome sequence of a bighorn sheep (Ovis canadensis)
Download2015
Moore, Stephen S., Miller, Joshua M., Coltman, David W., Liao, Xiaoping, Stothard, Paul
Background Whole genome sequences (WGS) have proliferated as sequencing technology continues to improve and costs decline. While many WGS of model or domestic organisms have been produced, a growing number of non-model species are also being sequenced. In the absence of a reference, construction...
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2007
Sawhney, Summit, Greiner, Russ, Querengesser, Lori, Shrivastava, Savita, Vogel, Hans J., Arndt, David, Macinnis, Glen D., Natalie, Zhang, Gavin E., Ying, Duggan, Tang, Peter, Amegbey, Godwin, Jewell, Kevin, Wagner, James, Clements, Tzur, Dan, Bamforth, Fiona, Young, Nelson, Miniaci, Jessica, Nikolai, Lisa, Eisner, Roman, Coutouly, Marie-Aude, Clive, Derrick, Li, Liang, Marrie, Tom, Block, David, Hau, David D., Cheng, Dean, Melisa, Gebremedhin, Stothard, Paul, Forsythe, Ian, Weljie, Alim M., Dowlatabadi, Reza, Wishart, David S., Sykes, Brian D., Fung, Chris, Knox, Craig, Jeroncic, Kevin, Mulu, Guo, Lewis, Mike, Guo, An Chi
The Human Metabolome Database (HMDB) is currently the most complete and comprehensive curated collection of human metabolite and human metabolism data in the world. It contains records for more than 2180 endogenous metabolites with information gathered from thousands of books, journal articles...
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Initial gut microbial composition as a key factor driving host response to antibiotic treatment, as exemplified by the presence or absence of commensal Escherichia coli
Download2017-08-01
Ju, Tingting, Shoblak, Yasmeen, Gao, Yanhua, Yang, Kaiyuan, Fouhse, Janelle, Finlay, B. Brett, So, Yee Wing, Stothard, Paul, Willing, Ben P.
Antibiotics are important for treating bacterial infection; however, efficacies and side effects of antibiotics vary in medicine and experimental models. A few studies have correlated microbiota composition variations with health outcomes in response to antibiotics; however, no study has...
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Kinome profiling of peripheral blood mononuclear cells collected prior to vaccination reveals biomarkers and potential mechanisms of vaccine unresponsiveness in pigs
Download2020-12-01
Lipsit, Sean W. L., Wilkinson, James, Scruten, Erin, Facciuolo, Antonio, Denomy, Connor, Griebel, Philip J., Kusalik, Anthony, Plastow, Graham, Napper, Scott
Inter-individual variance in host immune responses following vaccination can result in failure to develop protective immunity leaving individuals at risk for infection in addition to compromising herd immunity. While developing more efficacious vaccines is one strategy to mitigate this problem,...
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Metabolic flexibility revealed in the genome of the cyst-forming α-1 proteobacterium Rhodospirillum centenum
Download2010
Hao, Jicheng, Rollo, David, Marden, Jeremiah, Stothard, Paul, Kurdoglu, Ahmet A., Kim, Sun, Chowdhury, Sugata R., Mastrian, Stephen D., Swingley, Wesley D., Lu, Yih-Kuang , Touchman, Jeffrey W., Han, Mira, Blankenship, Robert E., Bauer, Carl E., Matthies, Heather J., Helmy,Tamer
Background Rhodospirillum centenum is a photosynthetic non-sulfur purple bacterium that favors growth in an anoxygenic, photosynthetic N2-fixing environment. It is emerging as a genetically amenable model organism for molecular genetic analysis of cyst formation, photosynthesis, phototaxis, and...