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Author / Creator / Contributor
- 1Benesch, Matthew G. K.
- 1Brindley, David N.
- 1Curtis, Jonathan M.
- 1Dewald, Jay
- 1McMullen, Todd P. W.
- 1Patwardhan, Neeraj
Subject / Keyword
- 1Autotaxin
- 1Breast Cancer
- 1Cell Migration
- 1Epidermal Growth Factor Receptor
- 1G-Protein-Coupled Receptors
- 1Lysophosphatidate
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Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice
Download2014
Dewald, Jay, Santos, Webster L., Patwardhan, Neeraj, Zhao, Yuan Y., McMullen, Todd P. W., Curtis, Jonathan M., Brindley, David N., Tang, Xiaoyun, Benesch, Matthew G. K.
Lipid phosphate phosphatase-1 (LPP1) degrades lysophosphatidate (LPA) and attenuates receptor-mediated signaling. LPP1 expression is low in many cancer cells and tumors compared with normal tissues. It was hypothesized from studies with cultured cells that increasing LPP1 activity would decrease...
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