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Zic transcription factors regulate retinoic acid metabolism during zebrafish neural development
DownloadSpring 2012
Retinoic acid (RA) has a crucial role in embryonic nervous system development - controlling anterior-posterior patterning, neural differentiation, and cell proliferation. During zebrafish embryogenesis, levels of RA are tightly regulated by the combinatorial action of synthesis and degradation...
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Fall 2019
Acting as a co-factor for hundreds of enzymes, zinc (Zn) is an essential trace metal required for organismal success across all phyla. When aquatic organisms such as fish are Zn deficient, growth, metabolism, and health are all negatively impacted. However, Zn in excess may also impair overall...
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Zinc in Precambrian iron formations: The record, partitioning, diagenetic effects and implications for eukaryotic metallome evolution
DownloadFall 2013
Zinc is amongst the most important trace elements for eukaryotes. Previous work has suggested it to have been at biolimiting concentrations for much of the Precambrian, thereby limiting eukaryotic evolution. Yet, the iron formation (IF) record, a critical proxy for paleomarine conditions, has...