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Preliminary validation of a computer-based approach to find new lead molecules targeting the oncogenic Forkhead box M1 transcription factor
DownloadFall 2017
The upregulation of the forkhead box M1 (FOXM1) transcription factor is directly correlated with cancer initiation, invasion, and drug resistance. Because the overexpression of FOXM1 is considered an important factor in carcinogenesis, this protein could be a relevant drug target in cancer...
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Spring 2018
Although the desire is strong among Canadaâs rapidly aging population to age-in-place, research reveals few have adequately prepared their current homes to support them later in life. While environmental gerontologists and occupational therapists have studied the meaning of home and the impact...
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Comparison of Trenchless Technologies and Open Cut Methods in New Residential Land Development
DownloadSpring 2018
Mahsa Ahmadian Nezhad Monfared
Nowadays, with the expansion of population in urban areas, development of new residential and commercial areas is essential to meet the needs of this ever-expanding population. Urban water and wastewater systems are fundamental infrastructure in this development, and are very important for high...
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Spring 2018
In contemporary scientific theories of evolution, organisms are construed as if they were the products of genes and gene-expression. Much of our biological research operate on the assumptions that (1) organisms are reducible to and reconstructible from their genes, and (2) the organism, as a...
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Fall 2017
In this time of truth and reconciliation, an Indigenous health research question was asked, responded to, and interpreted by people whose genealogy includes Cree, Blackfoot (Piikani), Kwakwaka’wakw, Stoney and Métis. Indigenous HIV in Canada is described from the point of view of those who live...
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Spring 2017
In this research, novel Modular Multilevel Converters (MMCs) intended for various type of power transmission systems are studied. Currently, the MMC, which is built based upon stack of identical half- or full-bridge submodules (SMs), is the dominant Voltage Source Converter (VSC) topology for...
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Multiple Outcomes in Heart Failure Research: Composite Endpoints and Multivariate Modelling
DownloadFall 2017
Composite endpoints are increasingly popular outcomes in clinical trials of heart failure. Uptake has outpaced guidance on their use and little consistency is seen in their construction. We must consider how best to handle multiple outcomes statistically and clinically, ie in a way that is both...
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Spring 2017
This study assessed the economic impacts of Alberta’s irrigated agriculture industry as of 2011 and evaluated the economic viability of expanding the irrigated crop land by 10% within the 13 irrigation districts in southern Alberta. Results of the economic impact assessment revealed that...
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Investigation into the Effects of Real-world Uncertainties on A Computer Model-based Leak Detection System for Liquid Pipelines
DownloadFall 2017
Leaks in oil pipeline systems can significantly affect the environment and lead to economic losses. Pipeline companies are working to improve existing methods to monitor their pipelines more effectively. Computer model-based leak detection methods detect leaks by analyzing the pipeline hydraulic...
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Fall 2017
Hydraulic fracturing is a technique to enhance hydrocarbon production by inducing fracture(s) into reservoir rock. A fracture is induced by injecting fluid into the reservoir at pressures greater than the formation breakdown pressure. The fracture(s) geometry, mode, initiation and propagation...